DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6966 and Fem1b

DIOPT Version :9

Sequence 1:	NP_001097796.1	Gene:	CG6966 / 41816	FlyBaseID:	FBgn0038286	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_034323.1	Gene:	Fem1b / 14155	MGIID:	1335087	Length:	627	Species:	Mus musculus

Alignment Length:	687	Identity:	240/687 - (34%)
Similarity:	356/687 - (51%)	Gaps:	96/687 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFNAARDNNLAQLKATLYNKSSVEVGSLIS--AKVNG--ATPLVISCRNGHYDIVEYLLTKCRAN 67
            |:.||.:..:..|.|.|.|:|..::..|:.  ::..|  :|||:|:.||||..:|..||...|..
Mouse     8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQ 72

  Fly    68 VEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRRGANVNSTTRTNSTPLRAACFDGHYEIV 132
            .:|.|:|.|||..|:.|..|||||.|||..:||:||..|||||.||.|||||||||||||..:||
Mouse    73 TQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIV 137

  Fly   133 KYLVHHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGSLQI 197
            ||||.:.|:..:||::.:||||||.||||..:.:|||...||.|..:..|.||||..||:|.:.|
Mouse   138 KYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDI 202

  Fly   198 LQLLLKHGATMDVDYYGMTPLLAASVTGHMPIVEHLITLPCVSRESRIHALELLGATYV-DRKR- 260
            ::.|:|..|.:.|:.:|||||..|:.:....:||.|::.....|.|||.|||||||::. ||:.
Mouse   203 VKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENY 267

  Fly   261 DMAAALNLWRRALEERAVEPP--LEKKVQEPVPAYEMVREVTSVEELEEMVLDPDEMRMQALVIR 323
            |:....:....|:.||..:..  |||:|..|:.||....|..:.:|||.:..|.|.:.|:.|::|
Mouse   268 DIMKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELEAIRQDRDALHMEGLIVR 332

  Fly   324 QRILGPTHPDTSYYIRFRGAHYADAGRFDRCIELWSYALTMQQKILQPLSPMTQSSLLSFAELFS 388
            :||||..:.|.|:.|.:|||.|||...|::||:||.:||.::||    .:..|...||.||::||
Mouse   333 ERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQK----GNRNTHKDLLRFAQVFS 393

  Fly   389 FM--LVEAGRLLPRGRVVPPIEPDSMLTIFYKAVKEVERGLAFTLEQQKDQQHPQKQLPAADKSP 451
            .|  |.||.:       .|.||     .:...:|.|:|:.:           :..|.:..||...
Mouse   394 QMIHLNEAVK-------APDIE-----CVLRCSVLEIEQSM-----------NRVKNISDADVHS 435

  Fly   452 SCSASSSASSSSSTTLLSAHQHDCNHDPNALSRTMISAIHIGCLLSSLLDTDALSPEMRRQVMGA 516
            :..                 .::||         :.:.:::.|:.:.    ...|.|.:.::...
Mouse   436 AMD-----------------NYECN---------LYTFLYLVCISTK----TQCSEEDQCRINKQ 470

  Fly   517 LYRLNRLKVRVRFDRTALHYACYREGTLAGRYPS--CQFPSVTLAKALLEVGADPNAIDEAGNTP 579
            :|.|..|..|.|...:.||.|......:...:.:  |.||:..:.|.||:.||:.||:|..||:.
Mouse   471 IYNLIHLDPRTREGFSLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSA 535

  Fly   580 LHLATMQPYVEPLSHI---------LLEGGAHLDTKNYAGETFESLLAPTPMHK--------IID 627
            ||:...  |..|:|..         |:|.|||.|..|...:        ||:.|        ::.
Mouse   536 LHIIVQ--YNRPISDFLTLHSIIISLVEAGAHTDMTNKQNK--------TPLDKSTTGVSEILLK 590

  Fly   628 PMKYTTLACLAARTIKKHDIRYEGTVPATLYEFIELH 664
            .....:|.|||||.::.:||.|:..:|.||.||:..|
Mouse   591 TQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6966	NP_001097796.1	Ank_2	10..112	CDD:289560	46/105 (44%)
		ANK	40..169	CDD:238125	73/130 (56%)
		ANK repeat	40..72	CDD:293786	14/33 (42%)
		ANK repeat	86..113	CDD:293786	17/26 (65%)
		Ank_2	87..177	CDD:289560	56/89 (63%)
		ANK	110..234	CDD:238125	62/123 (50%)
		ANK repeat	118..146	CDD:293786	17/27 (63%)
		ANK repeat	148..179	CDD:293786	16/30 (53%)
		ANK repeat	181..210	CDD:293786	12/28 (43%)
		Ank_4	182..234	CDD:290365	21/51 (41%)
		ANK	528..>612	CDD:238125	29/94 (31%)
		ANK repeat	529..573	CDD:293786	13/45 (29%)
		ANK repeat	575..607	CDD:293786	13/40 (33%)
Fem1b	NP_034323.1	Ank_2	11..117	CDD:315466	46/105 (44%)
		ANK 1	45..74		12/28 (43%)
		ANK repeat	48..85	CDD:293786	18/36 (50%)
		ANK	87..207	CDD:238125	67/119 (56%)
		ANK repeat	87..118	CDD:293786	18/30 (60%)
		ANK 2	87..116		17/28 (61%)
		Ank_2	101..>366	CDD:330894	120/264 (45%)
		ANK repeat	120..151	CDD:293786	20/30 (67%)
		ANK 3	120..149		20/28 (71%)
		ANK repeat	153..183	CDD:293786	16/29 (55%)
		ANK 4	153..182		15/28 (54%)
		ANK 5	186..215		12/28 (43%)
		ANK repeat	186..211	CDD:293786	11/24 (46%)
		ANK 6	218..248		10/29 (34%)
		ANK repeat	218..247	CDD:293786	9/28 (32%)
		TPR	344..377		17/36 (47%)
		ANK	478..>577	CDD:238125	31/108 (29%)
		ANK repeat	483..529	CDD:293786	13/45 (29%)
		ANK 7	483..527		11/43 (26%)
		ANK repeat	531..570	CDD:293786	13/40 (33%)
		ANK 8	531..568		12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X856
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810