DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6966 and fem1c

DIOPT Version :9

Sequence 1:	NP_001097796.1	Gene:	CG6966 / 41816	FlyBaseID:	FBgn0038286	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	XP_002931764.1	Gene:	fem1c / 100493200	XenbaseID:	XB-GENE-998529	Length:	617	Species:	Xenopus tropicalis

Alignment Length:	671	Identity:	335/671 - (49%)
Similarity:	428/671 - (63%)	Gaps:	62/671 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDYKFIVFNAARDNNLAQLKATLYNKSSVEVGSLISAKVNGATPLVISCRNGHYDIVEYLLTKCR 65
            ||.|..|||||||..|..|...|.||:..||..|:|.|.||||||:::.|.||.|:|:|||.:|.
Frog     1 MDLKTAVFNAARDGKLRLLSKLLENKAKDEVVVLMSEKTNGATPLLMAARYGHLDMVDYLLDQCS 65

  Fly    66 ANVEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRRGANVNSTTRTNSTPLRAACFDGHYE 130
            |:||..|||:||||.||.|||||.|:|||||.:|:.|:..||:||:||.||||||||||||||.|
Frog    66 ASVEIGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLDHGASVNNTTLTNSTPLRAACFDGHLE 130

  Fly   131 IVKYLVHHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGSL 195
            ||||||.|.||.|||||||||||||:|||||..|||:||...|||||.|||||||||||||||||
Frog   131 IVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSL 195

  Fly   196 QILQLLLKHGATMDVDYYGMTPLLAASVTGHMPIVEHLITLPCVSRESRIHALELLGATYVDRKR 260
            :|:|:|||:||.|:.|.|||||||:||||||..||:.|...|..|:..||:||||||||:||:||
Frog   196 EIMQMLLKYGARMEKDGYGMTPLLSASVTGHTNIVDFLTQHPQTSKIERINALELLGATFVDKKR 260

  Fly   261 DMAAALNLWRRALEER------AVEPPLEKKVQEPVPAYEMVREVTSVEELEEMVLDPDEMRMQA 319
            |:..||..|:||::.|      .:..|   :.|..:.||:..|||.:.|||:.::.|||||||||
Frog   261 DLLGALKYWKRAMDMRYSDRTNIISKP---EPQTLIMAYDYAREVNTAEELDNLIADPDEMRMQA 322

  Fly   320 LVIRQRILGPTHPDTSYYIRFRGAHYADAGRFDRCIELWSYALTMQQKILQPLSPMTQSSLLSFA 384
            |:||:|||||:|||||||||:|||.|||:|.|.|||.||.|||.|||..|.||||||.|||||||
Frog   323 LLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQNNLDPLSPMTASSLLSFA 387

  Fly   385 ELFSFMLVEAGRLLPRGRVVPPIEPDSMLTIFYKAVKEVERGLAFTLEQQKDQQHPQKQLPAADK 449
            |||||||.:..    :|.:...:..|.::.|..|:|.|::|.:       |....|..|:
Frog   388 ELFSFMLQDRA----KGLLGTTVTFDDLMGILCKSVMEIDRAV-------KQTAPPPDQV----- 436

  Fly   450 SPSCSASSSASSSSSTTLLSAHQHDCNHDPNALSRTMISAIHIGCLLSSLLDTDALSPEMRRQVM 514
                                           .|::.:...:|:.|||..:    ..||:......
Frog   437 -------------------------------QLNKALSIILHLICLLEKV----PCSPDQEHFKK 466

  Fly   515 GALYRLNRLKVRVRFDRTALHYACYREGTLAGRYPSCQFPSVTLAKALLEVGADPNAIDEAGNTP 579
            ..:||..:|..:.:.:.:.||.|..:..|..||||.|:|||..:...|||.|||.|..|...|:|
Frog   467 QNIYRFLKLHPKGKNNFSPLHLAVDKNTTCVGRYPVCKFPSFQVTAILLECGADVNVRDAEQNSP 531

  Fly   580 LHLATMQPYVEPLSHILLEGGAHLDTKNYAGETFESLLAPTPMHK-IIDPMKYTTLACLAARTIK 643
            ||:|.:..:.: :.::|::.|||.|:.|...:|...||....|.| :|.|:.:|||.|||||.|.
Frog   532 LHIAALNNHPD-IMNLLVKSGAHFDSTNSHNQTACDLLDEKEMAKNLIQPINHTTLQCLAARVIV 595

  Fly   644 KHDIRYEGTVPATLYEFIELH 664
            ||:|:|:..:|..|..|:.||
Frog   596 KHNIQYKQEIPEKLESFVLLH 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6966	NP_001097796.1	Ank_2	10..112	CDD:289560	58/101 (57%)
		ANK	40..169	CDD:238125	91/128 (71%)
		ANK repeat	40..72	CDD:293786	18/31 (58%)
		ANK repeat	86..113	CDD:293786	15/26 (58%)
		Ank_2	87..177	CDD:289560	66/89 (74%)
		ANK	110..234	CDD:238125	96/123 (78%)
		ANK repeat	118..146	CDD:293786	23/27 (85%)
		ANK repeat	148..179	CDD:293786	23/30 (77%)
		ANK repeat	181..210	CDD:293786	23/28 (82%)
		Ank_4	182..234	CDD:290365	38/51 (75%)
		ANK	528..>612	CDD:238125	31/83 (37%)
		ANK repeat	529..573	CDD:293786	19/43 (44%)
		ANK repeat	575..607	CDD:293786	10/31 (32%)
fem1c	XP_002931764.1	ANK repeat	5..38	CDD:293786	16/32 (50%)
		Ank_2	10..110	CDD:372319	56/99 (57%)
		ANK repeat	40..75	CDD:293786	20/34 (59%)
		ANK repeat	82..113	CDD:293786	18/30 (60%)
		Ank_2	87..178	CDD:372319	67/90 (74%)
		ANK repeat	118..146	CDD:293786	23/27 (85%)
		ANK repeat	148..179	CDD:293786	23/30 (77%)
		Ank_2	153..236	CDD:372319	60/82 (73%)
		PHA02876	<164..>554	CDD:165207	199/444 (45%)
		ANK repeat	181..209	CDD:293786	22/27 (81%)
		ANKYR	<457..599	CDD:223738	54/142 (38%)
		ANK repeat	481..525	CDD:293786	19/43 (44%)
		ANK repeat	527..552	CDD:293786	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2925
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10606
Inparanoid	1	1.050	602	1.000	Inparanoid score	I929
OMA	1	1.010	-	-		QHG48454
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	1	1.000	-	-		FOG0003207
OrthoInspector	1	1.000	-	-		oto103987
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4568
SonicParanoid	1	1.000	-	-		X856
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110