DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and mep1a.2

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001122199.1	Gene:	mep1a.2 / 565535	ZFINID:	ZDB-GENE-041001-208	Length:	689	Species:	Danio rerio

Alignment Length:	235	Identity:	85/235 - (36%)
Similarity:	114/235 - (48%)	Gaps:	37/235 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EIHIDDEQ-------AEAKTRNALTSPLQRW--PGNKILYRISTDYSEQEVANV-RTAMSSFGEQ 88
            ||::|.::       |....|||:.....||  |   |.| |.||..:.....| ..|:..:..:
Zfish    40 EINLDSQRELFEGDIAGDPRRNAIIDEKARWQFP---IPY-ILTDTLDLNAKGVILQALEMYRLK 100

  Fly    89 TCVQFEEIEGAPPAGKRYVSFKKSPNMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLL 153
            :||.|:..||.    ..|:||.|... |.:.||  .|..| ..|.:.|:|.| .|:::||.||.|
Zfish   101 SCVDFKPYEGE----STYISFTKLDG-CWSFVG--DLKTG-QNVSIGERCDT-KAIVEHELLHAL 156

  Fly   154 GLFHEQSRPDRDEYVQIDYDNIP-------RKYWSQFMAMDQTTTFNVPYDYESVMHYSKNAFAK 211
            |.:|||||.|||:||:|.:|.|.       .||...|:     |..|.||||||:|||...:|.|
Zfish   157 GFYHEQSRSDRDDYVKIWWDQIIEGKEHNFNKYEDDFI-----TDLNTPYDYESIMHYRPLSFNK 216

  Fly   212 DPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            ||..|||...|  .|....:||....|..|..::..||:|
Zfish   217 DPDIPTITTTI--PAFNNIIGQRLDFSALDLERLNRMYEC 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	77/205 (38%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	72/197 (37%)
mep1a.2	NP_001122199.1	ZnMc	26..254	CDD:294052	84/233 (36%)
		Astacin	68..256	CDD:279708	78/207 (38%)
		MAM	259..423	CDD:214533
		MAM	264..423	CDD:99706
		MATH	423..579	CDD:295307
		EGF	619..653	CDD:278437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910