DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and tll1

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_571085.1	Gene:	tll1 / 474335	ZFINID:	ZDB-GENE-041020-1	Length:	1022	Species:	Danio rerio

Alignment Length:	252	Identity:	71/252 - (28%)
Similarity:	124/252 - (49%)	Gaps:	16/252 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLLL-----AGIFAPNLVASEGIESYENYYNEIHIDDEQAEAKTRNALTSPLQR-WPGNKILYRI 66
            ||||     .|..:..:.:|:.:.|.:.....:: .....:::...|.||..:: |||..|.|.|
Zfish   112 YLLLDRIRRLGFESWPVNSSKDVSSIKTGIRRVN-SARNVKSRVPRAATSRAEKIWPGGVIPYVI 175

  Fly    67 STDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVSFKKSPNMCGTRVGYQPLSFGPHE 131
            ..:::..:.|.::.||..:.:||||.|.|    ....:.|:.|...|..|.:.||.:  ..||..
Zfish   176 GGNFTGSQRAMLKQAMRHWEKQTCVTFIE----KTDEESYIVFTYRPCGCCSYVGRR--GNGPQA 234

  Fly   132 VVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNIPRKYWSQFMAMD--QTTTFNV 194
            :.:.:.|... .::.||..|::|.:||.:|||||::|.|..|||.......|:.|:  ...:...
Zfish   235 ISIGKNCDKF-GIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGE 298

  Fly   195 PYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            |||::|:|||::|.|::.....||........|...:||....|:||.::.:.:|:|
Zfish   299 PYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPAIGQRTRLSKGDISQAKKLYRC 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	60/198 (30%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	57/191 (30%)
tll1	NP_571085.1	ZnMc_BMP1_TLD	157..356	CDD:239808	64/206 (31%)
		Astacin	164..357	CDD:279708	61/199 (31%)
		CUB	358..467	CDD:278839
		CUB	471..580	CDD:278839
		FXa_inhibition	591..623	CDD:291342
		CUB	627..736	CDD:278839
		FXa_inhibition	743..778	CDD:291342
		CUB	783..892	CDD:278839
		CUB	896..1009	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810