DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and tok

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001287510.1	Gene:	tok / 42944	FlyBaseID:	FBgn0004885	Length:	1464	Species:	Drosophila melanogaster

Alignment Length:	217	Identity:	64/217 - (29%)
Similarity:	109/217 - (50%)	Gaps:	8/217 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DDEQAEAKTRNALTSPLQR-WPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPP 101
            |:|....:...|:|:..:| |....|.|.|..::|....|..:.||..:...||::|  :|..|.
  Fly   509 DEEPLRHRVARAVTAKKERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKF--VERDPE 571

  Fly   102 AGKRYVSFKKSPNMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDE 166
            ....|:.|......|.:.||.:  ..||..:.:...|... .::.||..|::|.:||.:||||::
  Fly   572 IHPNYIVFTVRSCGCCSFVGKR--GNGPQAISIGRNCDKF-GIVVHELGHVVGFWHEHTRPDREK 633

  Fly   167 YVQIDYDNIPR--KYWSQFMAMDQTTTFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVER 229
            :|.|:::||.:  .|....::.|:..:..:.|||:|:|||::|.|:|.....||..:........
  Fly   634 HVVIEHNNIMKGQDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRP 698

  Fly   230 EMGQVRGPSEGDWTKIRLMYKC 251
            |:||....|:||..:..|:|||
  Fly   699 EIGQRLRLSQGDIAQANLLYKC 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	58/198 (29%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	55/191 (29%)
tok	NP_001287510.1	ZnMc_BMP1_TLD	520..721	CDD:239808	62/206 (30%)
		Astacin	527..721	CDD:279708	60/199 (30%)
		CUB	723..836	CDD:294042
		CUB	840..951	CDD:278839
		FXa_inhibition	958..993	CDD:291342
		CUB	997..1111	CDD:278839
		FXa_inhibition	1118..1153	CDD:291342
		CUB	1158..1267	CDD:278839
		CUB	1271..1390	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840