DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and MEP1B

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens

Alignment Length:	269	Identity:	88/269 - (32%)
Similarity:	134/269 - (49%)	Gaps:	41/269 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLKAVRYLLLAGIFAP-NLVASEGIE----------SYENYYNEIHIDDEQAEAKTRNALTSPL 54
            :||.|:  |:::|:..| |.....|::          ..:.:..:|.:|    .|:.||::....
Human    10 LFLDAL--LVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLD----RAQIRNSIIGEK 68

  Fly    55 QRWPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGK-RYVS-FKKS---PN 114
            .||| :.|.|.:...........:..|...:..:||:.|:     |.||: .|:| ||.|   .:
Human    69 YRWP-HTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFK-----PWAGETNYISVFKGSGCWSS 127

  Fly   115 MCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNI--PR 177
            :...|||.|.||.|.:       |..: |.:|||.||.||.:|||||.|||:||:|.:|.|  .|
Human   128 VGNRRVGKQELSIGAN-------CDRI-ATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGR 184

  Fly   178 KYWSQFMAMDQTTTFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDW 242
            ::.....:.|.:.:.||||||.|||||||.|| ::.::|||...|..  .|..:||....|:.|.
Human   185 EHNFNTYSDDISDSLNVPYDYTSVMHYSKTAF-QNGTEPTIVTRISD--FEDVIGQRMDFSDSDL 246

  Fly   243 TKIRLMYKC 251
            .|:..:|.|
Human   247 LKLNQLYNC 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	74/202 (37%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	70/196 (36%)
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	81/249 (33%)
		Astacin	69..257	CDD:279708	75/204 (37%)
		MAM	260..427	CDD:214533
		MAM	265..427	CDD:99706
		MATH	427..586	CDD:295307
		Required for proteolytic processing	595..607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910