DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and CG42255

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster

Alignment Length:	268	Identity:	56/268 - (20%)
Similarity:	93/268 - (34%)	Gaps:	62/268 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GIESYENYYNEIHIDDEQAEAKTRNALTSPLQRWPGNKILYRI-------STDYSEQEVANVRTA 81
            |.||......|..:   :...:.|....|||.||  .::.|::       ||.::.:...|..:
  Fly  2989 GEESIGRLCPEFEV---KGNGRVRLRYVSPLSRW--FEMQYQLIQCGGNYSTSFTLRPPQNEDS- 3047

  Fly    82 MSSFGEQTCVQFEEIEGAPPAGKRYVSFKKSPNMCGTRVGYQPLSFGPHEVVLNEK-----C--L 139
             |.:...|..::...  |||.....:.||..........|:..|:.....||..|:     |  :
  Fly  3048 -SVYAHNTLCEWRIT--APPQHAVVIEFKYFDMESSRNCGFDSLTIYRGHVVSEEQRTGLLCGNV 3109

  Fly   140 TMPAVI---QHETLHLLGLFHEQS----------RPDRDEYVQIDYDNIPRKYWSQFMAMDQTTT 191
            |.|..|   .:|.|.:|......|          .|:.:|:|.:|.: :||      |::.:...
  Fly  3110 TNPETIIVNSNEALIVLTTDSSNSYRGFLASVRFTPNCNEHVALDLE-VPR------MSVMRQYV 3167

  Fly   192 FNV------------PYDYESVMHYSKNAFAKDPSKPTIRAL-------IGGKAVEREMGQVRGP 237
            .|:            |.||...:...|...|.|....|...|       :.|:.:.|..|...|.
  Fly  3168 VNISESLLCIFQASAPPDYRISLEVRKLQLADDVVCRTCSYLEIHDSKDVEGQNLGRYYGGTNGN 3232

  Fly   238 SEGDWTKI 245
            ...:.||:
  Fly  3233 EPSNRTKV 3240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	48/237 (20%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	46/233 (20%)
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001
		CUB	1066..1179	CDD:238001
		CUB	1185..1293	CDD:238001
		CUB	1303..1406	CDD:238001
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001	23/117 (20%)
		CUB	3169..3249	CDD:294042	15/72 (21%)
		CUB	3499..3607	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830