DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and Tll2

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001178827.1	Gene:	Tll2 / 365460	RGDID:	1559756	Length:	1014	Species:	Rattus norvegicus

Alignment Length:	211	Identity:	64/211 - (30%)
Similarity:	106/211 - (50%)	Gaps:	10/211 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AKTRNALTSPLQR-WPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYV 107
            |:.|.|.||..:| |||..|.|.|..:::..:.|..:.||..:.:.|||.|.|....    :.::
  Rat   144 ARVRRATTSRTERIWPGGVIPYVIGGNFTGTQRAIFKQAMRHWEKHTCVTFIERTDE----ESFI 204

  Fly   108 SFKKSPNMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDY 172
            .|......|.:.||.:  ..||..:.:.:.|... .::.||..|::|.:||.:|||||::|.|..
  Rat   205 VFSYRTCGCCSYVGRR--GGGPQAISIGKNCDKF-GIVAHELGHVVGFWHEHTRPDRDQHVTIIR 266

  Fly   173 DNIPRKYWSQFMAMD--QTTTFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVR 235
            :||.......|:.|:  :.::....||::|:|||::|.|::.....||........|...:||..
  Rat   267 ENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRV 331

  Fly   236 GPSEGDWTKIRLMYKC 251
            ..|:||..:.|.:|||
  Rat   332 RLSQGDIAQARKLYKC 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	57/198 (29%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	53/191 (28%)
Tll2	NP_001178827.1	ZnMc_BMP1_TLD	149..348	CDD:239808	62/206 (30%)
		Astacin	156..349	CDD:279708	59/199 (30%)
		CUB	350..459	CDD:278839
		CUB	463..572	CDD:278839
		FXa_inhibition	583..615	CDD:291342
		CUB	619..728	CDD:278839
		FXa_inhibition	735..770	CDD:291342
		CUB	775..884	CDD:278839
		CUB	888..1001	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810