DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and nas-23

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001022281.1	Gene:	nas-23 / 3565992	WormBaseID:	WBGene00003542	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	272	Identity:	75/272 - (27%)
Similarity:	113/272 - (41%)	Gaps:	50/272 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AGIFAPNLVASEGIESYEN---------YYNEIHID------------DEQAEAKT--RNALTSP 53
            ||:..|....::.:.|..:         :..:||:.            |.....:|  |||: .|
Worm    57 AGVSLPKHEYTDRLSSISDLNRSKRDLLFQGDIHLSFEHLSNIVREQLDHSRTKRTAFRNAM-YP 120

  Fly    54 LQRWPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVSFKKSPNMCGT 118
            ...|..| :.:.:....|.:..:::..||:.:.:.|||.|::    ..:.|.|:........|.:
Worm   121 KTIWLPN-VPFELHGSLSAKSRSSLVAAMAFWEKHTCVAFKK----RTSEKVYLLMSGQEEGCWS 180

  Fly   119 RVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNIPRKYWSQF 183
            .||..... |...:.:...| .|..:..||..|.|||||||||.|||.||||....|.:..:..|
Worm   181 TVGRDEAQ-GAQILNIGTGC-EMFGITSHEIAHALGLFHEQSRYDRDNYVQIVKSRIAQTNFYDF 243

  Fly   184 MAMDQTT--TFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAV-------EREMGQVRGPSE 239
            ..:.:..  |:...||..|||||          :||..:|.||.::       :..|||.||||.
Worm   244 AVVGKKNMETYGQKYDIGSVMHY----------RPTEFSLDGGNSIIAKDVNMQNTMGQFRGPSF 298

  Fly   240 GDWTKIRLMYKC 251
            .|..||...|.|
Worm   299 IDVAKINRHYNC 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	62/204 (30%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	60/198 (30%)
nas-23	NP_001022281.1	Astacin	122..310	CDD:279708	62/204 (30%)
		ZnMc_astacin_like	128..308	CDD:239807	59/195 (30%)
		CUB	384..454	CDD:294042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14369
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910