DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and Mep1b

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_037315.1	Gene:	Mep1b / 25727	RGDID:	3081	Length:	704	Species:	Rattus norvegicus

Alignment Length:	261	Identity:	85/261 - (32%)
Similarity:	126/261 - (48%)	Gaps:	24/261 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLKAVRYLLLAGIFAPNLVASE---GIESYENYYNE-IHID----DEQAEAKTRNALTSPLQRWP 58
            ||....:||::|:.||.....:   ||:......|| :.:|    |.:.||..||::.....|||
  Rat     9 FLVFATFLLVSGLPAPEKFVKDIDGGIDQDIFDINEDLGLDLFEGDIKLEASGRNSIIGDNYRWP 73

  Fly    59 GNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVS-FKKSPNMCGTRVGY 122
             :.|.|.:...........:..|...:..:||:.|:...|.    :.|:| ||.|.  |.:.||
  Rat    74 -HTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWSGE----ENYISVFKGSG--CWSSVG- 130

  Fly   123 QPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNIPRKYWSQFMAMD 187
             .:..|..|:.:...|..: |.:|||.||.||.:|||||.|||:|:.|.:|.|.......|...:
  Rat   131 -NIHAGKQELSIGTNCDRI-ATVQHEFLHALGFWHEQSRADRDDYITIVWDRILSGKEHNFNIYN 193

  Fly   188 QTT--TFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYK 250
            .:.  :.||||||.|||||||.|| ::.::.||...|..  .|..:||....|:.|..|:..:|.
  Rat   194 DSVSDSLNVPYDYTSVMHYSKTAF-QNGTESTIITKISD--FEDVIGQRMDFSDYDLLKLNQLYS 255

  Fly   251 C 251
            |
  Rat   256 C 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	67/198 (34%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	63/192 (33%)
Mep1b	NP_037315.1	ZnMc	30..256	CDD:294052	77/238 (32%)
		Astacin	70..258	CDD:279708	68/200 (34%)
		MAM	266..430	CDD:279023
		MAM	266..428	CDD:99706
		MATH	428..586	CDD:295307
		EGF_CA	609..647	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910