DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and Astl

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001277932.1	Gene:	Astl / 215095	MGIID:	3046414	Length:	435	Species:	Mus musculus

Alignment Length:	243	Identity:	68/243 - (27%)
Similarity:	106/243 - (43%)	Gaps:	33/243 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SEGIESYENYYNEIHIDDEQAEAKTRNALTSPLQRWPGN-----KILYRISTDYSEQEVANVRTA 81
            ::|:.|.|...:...::.:.........|:....:||..     :|.:.:|..|.|.....:..|
Mouse    59 NQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDA 123

  Fly    82 MSSFGEQTCVQFEEIEG-------APPAGKRYVSFKKSPNMCGTRVGYQPLSFGPHEVVLNEKCL 139
            .:.|...||::|....|       .|.||            |.:.||   .|.|...|.|...||
Mouse   124 FAEFERFTCIRFVAYHGQRDFVSILPMAG------------CFSGVG---RSGGMQVVSLAPTCL 173

  Fly   140 TM-PAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNIPRKYWSQFMAMDQTTTFNVPYDYESVMH 203
            .. ..::.||.:|:||.:||.||.|||.|:|::::.|...:...|: ..::|...|||||.||||
Mouse   174 RKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFI-KSRSTNMLVPYDYSSVMH 237

  Fly   204 YSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            |.:.||:. ..:|||..|.....   .:||....|..|.|::..:|.|
Mouse   238 YGRFAFSW-RGQPTIIPLWTSSV---HIGQRWNLSTSDITRVCRLYNC 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	63/208 (30%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	60/202 (30%)
Astl	NP_001277932.1	Astacin	92..282	CDD:279708	64/210 (30%)
		ZnMc	100..281	CDD:294052	61/200 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910