DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and nas-33

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_509086.2	Gene:	nas-33 / 186987	WormBaseID:	WBGene00003551	Length:	644	Species:	Caenorhabditis elegans

Alignment Length:	185	Identity:	58/185 - (31%)
Similarity:	89/185 - (48%)	Gaps:	34/185 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 WPGNKILYR-ISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVSFKKSPNMCGTRV 120
            |..| |.|| :.||.:.|  :.:...:..:...||::| .:.|   .|..|:.|.|... |.:.|
Worm   202 WSRN-IPYRFLDTDGNWQ--SQITNGLRHYERNTCIRF-SLNG---GGSDYLVFSKGEG-CYSSV 258

  Fly   121 GYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDN--------IPR 177
            |...   ||.|:.:.:.|.|: .:|.||..|.||.:|||:||:||.||:|:..|        ..:
Worm   259 GRLG---GPQEISIGDGCETL-GIITHEVGHALGFWHEQARPERDSYVRINRQNAINGLEGQFDK 319

  Fly   178 KYWSQFMAMDQTTTFNVPYDYESVMHYSKNAFAK-------DPSKPTIRALIGGK 225
            :.||      :...:::||||.|||||...:|:|       :|..|.....||.:
Worm   320 RSWS------EVNEYSLPYDYGSVMHYGPKSFSKSSTMNTVEPVDPAFINTIGNR 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	58/185 (31%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	57/183 (31%)
nas-33	NP_509086.2	Astacin	200..386	CDD:279708	58/185 (31%)
		ZnMc_astacin_like	203..381	CDD:239807	57/184 (31%)
		CUB	442..527	CDD:294042
		TSP1	553..595	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6774
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14369
orthoMCL	1	0.900	-	-		OOG6_111101
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6486
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770