DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and nas-29

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_494953.3	Gene:	nas-29 / 186488	WormBaseID:	WBGene00003547	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	221	Identity:	66/221 - (29%)
Similarity:	100/221 - (45%)	Gaps:	16/221 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 IDDEQAEAKTRNALTS---PLQRWPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEG 98
            |:.|..:...|.|...   |...|. |.:.:......:......:..|:..:..:||::|.
Worm   124 INGESTDRTKRQAYLDNNYPATIWK-NGVAFMFHESLTPIAKTAILKAVHFWYRETCIEFH---- 183

  Fly    99 APPA-GKRYVSFKKSPNMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRP 162
             |.. .|.|:.|..:.:.|.:.|| :..|.|...|.:...|... .|..||..|.||:||||||.
Worm   184 -PRTFQKEYLLFIGNDDGCWSTVG-RDASQGKQVVSIGNGCEHF-GVTSHELAHALGIFHEQSRF 245

  Fly   163 DRDEYVQIDYDNIPRKYWSQFMAMD--QTTTFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGK 225
            ||||.|..:...:.|.....|..:.  |.:|:.:|||..|||||:...|:..||.||:.|:  ..
Worm   246 DRDESVVFNPRVVERDLLFNFAKISPRQMSTYGLPYDIGSVMHYTPTEFSNIPSIPTLAAI--DT 308

  Fly   226 AVEREMGQVRGPSEGDWTKIRLMYKC 251
            .:::.|||:.|||..|...:...|:|
Worm   309 NLQQTMGQLEGPSFVDVHIMNQHYQC 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	60/198 (30%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	58/192 (30%)
nas-29	NP_494953.3	Astacin	145..336	CDD:279708	61/200 (31%)
		ZnMc_astacin_like	148..332	CDD:239807	58/193 (30%)
		CUB	404..491	CDD:214483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14369
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920