DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and nas-28

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_498342.3	Gene:	nas-28 / 185658	WormBaseID:	WBGene00003546	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	250	Identity:	81/250 - (32%)
Similarity:	118/250 - (47%)	Gaps:	36/250 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SEGIESYENYYNEIHIDDEQAE-----------AKTRNALTSPLQRWPGN-KILYRISTDYSEQE 74
            ::.|..| .:.::|.::::||:           ...|.|:......|..: .|.|:..|..|...
Worm    85 NQDINEY-TFESDIMLNEKQAKHIATAIENGNYRSKRQAIVDTTNFWSVSVPIFYQFDTKLSATN 148

  Fly    75 VANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVSFKKSPNMCGTRVG------YQPLSFGPHEVV 133
            :||||.|:..:.:.:|:.|:|...|     :...|..|...|.:.||      ||.:|.||:
Worm   149 IANVRKAIQFWNDNSCLSFKEDNNA-----KNRLFLSSAGGCWSYVGKQVDMPYQMVSVGPN--- 205

  Fly   134 LNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNI--PRKYWSQFMAMDQTTTFNVPY 196
                |.|. ....||.:|.:|.:|:|||.|||.||.:|:.||  .:.|..|.||:||....|:||
Worm   206 ----CDTF-GTATHELMHAIGFWHQQSRADRDNYVYVDFSNIIPSQAYNFQKMAVDQAQLLNLPY 265

  Fly   197 DYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            ||.|||.|...|||.|.||.||.|...|  .:..|||...|:..|...:..:|.|
Worm   266 DYGSVMQYYPYAFAVDSSKYTILAKENG--FQNSMGQREAPAFSDIIGVNKLYNC 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	73/204 (36%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	71/198 (36%)
nas-28	NP_498342.3	Astacin	135..320	CDD:279708	72/198 (36%)
		ZnMc_astacin_like	135..316	CDD:239807	71/195 (36%)
		CUB	393..480	CDD:214483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6774
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14369
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870