DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and nas-14

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_502533.2	Gene:	nas-14 / 184247	WormBaseID:	WBGene00003533	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	238	Identity:	76/238 - (31%)
Similarity:	111/238 - (46%)	Gaps:	50/238 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 IDDEQAEAK----TRNALTSPLQRWPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIE 97
            :|:::...|    ..|.:|.|.:.||..::.|.:....:..:...:..|...:..:|||:|
Worm   101 LDEDEIFRKPFHSALNLVTYPDKLWPEGQVPYMLEEGMTNDQRTAIAQAFDEYKTKTCVRF---- 161

  Fly    98 GAPPAG--------KRYVSFKKSPNMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLG 154
             .|...        ||.|:|..| :..|...|.|.:|.   ||   :||.: ..:|.||.:|.||
Worm   162 -VPKTDDDFDYIYVKRNVAFGCS-SYVGRAGGNQTVSL---EV---DKCFS-KGIIAHELMHALG 217

  Fly   155 LFHEQSRPDRDEYVQIDYDNI-----------PRKYWSQFMAMDQTTTFNVPYDYESVMHYSKNA 208
            .|||.||.|||::|.|:.|||           |||.         ..:..:||||||||||.|.|
Worm   218 FFHEHSRTDRDDFVDINEDNIRPGMMRNFEKYPRKI---------IDSLGMPYDYESVMHYHKLA 273

  Fly   209 FAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            |::: .||||..    |..|.::||....||.|..|:..:|:|
Worm   274 FSRN-GKPTIIP----KDNEADVGQRYKLSEMDSKKVNKLYQC 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	70/214 (33%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	67/208 (32%)
nas-14	NP_502533.2	Astacin	123..313	CDD:279708	71/216 (33%)
		ZnMc_astacin_like	128..309	CDD:239807	67/207 (32%)
		ShKT	380..414	CDD:214586
		ShK	468..503	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820