DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and nas-12

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_501871.2	Gene:	nas-12 / 182848	WormBaseID:	WBGene00003531	Length:	384	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	61/234 - (26%)
Similarity:	93/234 - (39%)	Gaps:	60/234 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IFAPNLVASEGIESYENYYNEIHIDDEQAEAKTRNALTSPLQRWPGNKILYRISTDYSEQEVANV 78
            :|...|:....:..|||      ..|.....:..:...|.:.||..|.:.|.||..||..:...:
Worm    46 VFGDMLLTPAQLIRYEN------SKDSDLSIRGVSIKGSSMNRWSNNIVPYVISPQYSPAQKQIL 104

  Fly    79 RTAMSSFGEQTCVQFEE------------IEGAPPAGKRYVSFKKSPNMCGTRVGYQPLSFGPHE 131
            .:::..|...:|.:|.|            ::|.    ..||         |...|.|.||
Worm   105 VSSLRYFERVSCFKFVERTTQNDYLFIVPLDGC----YSYV---------GKIGGRQTLS----- 151

  Fly   132 VVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDN-IPRKYWSQFMAMDQTTTFNVP 195
              |...|:. ..:|.||.:|.:|..||..|||||.::::||.| ||    .|.:..|:..|.:|.
Worm   152 --LAADCIA-DYIIWHEMMHAIGFEHEHQRPDRDSFIRVDYANVIP----GQMINFDKLKTSHVE 209

  Fly   196 ----YDYESVMHYSKNAFAK------------DPSKPTI 218
                ||::|:|||...||.:            .|.||.:
Worm   210 YPDIYDFKSIMHYDGYAFGRVDTARRVRLATMTPLKPGV 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	54/193 (28%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	52/189 (28%)
nas-12	NP_501871.2	Astacin	81..272	CDD:279708	54/193 (28%)
		ZnMc_astacin_like	85..267	CDD:239807	52/189 (28%)
		ShK	286..325	CDD:279838
		ShK	347..384	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920