DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and nas-15

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_508154.2	Gene:	nas-15 / 180426	WormBaseID:	WBGene00003534	Length:	571	Species:	Caenorhabditis elegans

Alignment Length:	250	Identity:	74/250 - (29%)
Similarity:	113/250 - (45%)	Gaps:	36/250 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SEGIESYENYYNEIHIDDEQA---------------EAKTRNALTSPLQRWPGNKILYRISTDYS 71
            |:.:.|.:.:..:|..|:..|               :.|..||:.:.||.||..:|.|.||:.||
Worm    73 SDAMYSKDRFEGDIANDNLNASTAELFANGGSGKSEDGKWYNAIKNRLQLWPEGRIPYTISSQYS 137

  Fly    72 EQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVSF---KKSPNMCGTRVGYQPLSFGPHEVV 133
            ....:.:..:|..:...||:::...|.   |...||..   :...:|.|...|.|.||.|
Worm   138 SYSRSLIAASMQEYASHTCIRWVPKEA---ADVNYVHIYPDRGCYSMVGKMGGKQSLSLG----- 194

  Fly   134 LNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNIPRKYWSQFMAMDQTT--TFNVPY 196
              ..|: ...:|.||.:|.:|.||||||.|||:::.|.::||......||......|  :....|
Worm   195 --SGCI-QKGIILHELMHAVGFFHEQSRTDRDDHITIMWNNIQAGMQGQFEKYGHGTIQSLGTGY 256

  Fly   197 DYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            ||.|:|||...||::: .:||:.....|..:    ||..|.|:.|..||..:|.|
Worm   257 DYGSIMHYGTKAFSRN-GQPTMIPKKNGATI----GQRNGFSKVDKFKINTLYGC 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	64/200 (32%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	60/194 (31%)
nas-15	NP_508154.2	Astacin	121..308	CDD:279708	64/201 (32%)
		ZnMc_astacin_like	126..304	CDD:239807	60/193 (31%)
		ShKT	354..388	CDD:214586
		ShK	436..471	CDD:279838
		Gag_MA	<472..531	CDD:279482
		ShK	535..571	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920