DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and Mep1b

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_032612.2	Gene:	Mep1b / 17288	MGIID:	96964	Length:	704	Species:	Mus musculus

Alignment Length:	270	Identity:	85/270 - (31%)
Similarity:	129/270 - (47%)	Gaps:	42/270 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLKAVRYLLLAGIFAPNLVASE----------------GIESYENYYNEIHIDDEQAEAKTRNAL 50
            ||....:||::|:.||.....:                |::.:|.        |.:.||..:|::
Mouse     9 FLVFATFLLVSGLPAPEKFVKDIDGGIDQDIFDINQGLGLDLFEG--------DIKLEANGKNSI 65

  Fly    51 TSPLQRWPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGK-RYVS-FKKSP 113
            ....:||| :.|.|.:...........:..|...:..:||:.|:     |.:|: .|:| ||.|.
Mouse    66 IGDHKRWP-HTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFK-----PWSGEANYISVFKGSG 124

  Fly   114 NMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNI-PR 177
              |.:.||  .:..|..|:.:...|..: |.:|||.||.||.:|||||.|||:||.|.:|.| |.
Mouse   125 --CWSSVG--NIHAGKQELSIGTNCDRI-ATVQHEFLHALGFWHEQSRADRDDYVIIVWDRIQPG 184

  Fly   178 KYWSQFMAMDQTT-TFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGD 241
            |..:..:..|..: :.||||||.|||||||.|| ::.::.||...|  ...|..:||....|:.|
Mouse   185 KEHNFNIYNDSVSDSLNVPYDYTSVMHYSKTAF-QNGTESTIVTRI--SEFEDVIGQRMDFSDYD 246

  Fly   242 WTKIRLMYKC 251
            ..|:..:|.|
Mouse   247 LLKLNQLYNC 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	71/199 (36%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	67/193 (35%)
Mep1b	NP_032612.2	ZnMc	30..256	CDD:294052	77/247 (31%)
		Astacin	70..258	CDD:279708	72/201 (36%)
		MAM	266..430	CDD:279023
		MAM	266..428	CDD:99706
		MATH	428..587	CDD:295307
		EGF_CA	609..647	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910