DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and astl2d.5

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_031756347.1	Gene:	astl2d.5 / 100495579	XenbaseID:	XB-GENE-22069752	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	253	Identity:	71/253 - (28%)
Similarity:	105/253 - (41%)	Gaps:	45/253 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IFAPNLVASEGIESYENYYNEI-HIDDEQAEAKTRNALTSPLQRWPGNK----ILYRISTDYSEQ 73
            :|:..|.|::|        |.: .:.::.|...:|:|:|.....|....    :.|.:...||..
Frog    43 VFSRILKANQG--------NRVPRVQEDIAVGVSRSAITYTECLWQKTNGTVYVPYTLDDKYSNS 99

  Fly    74 EVANVRTAMSSFGEQTCVQF----EEIEGAPPAGKRYVSFKKSPNMCGTRVGYQPLSFGPHEVVL 134
            ||..:.:||..:...|||||    :|.:        ||:. .|.:.|.:.:|.|.   |...|.:
Frog   100 EVNTMTSAMEVYATLTCVQFVPYTDEDD--------YVNI-TSGDGCWSYMGRQR---GAQVVSV 152

  Fly   135 NEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNIPRKYWSQFMAMDQTTTFNVPYDYE 199
            .:...|......||..|.||..|||||.|||.||.|.|..|.....::|..| ::......|||.
Frog   153 EKGYCTSEGTTMHELNHALGFVHEQSRSDRDNYVNIMYQYISPGDVAEFKKM-ESNNLGTTYDYR 216

  Fly   200 SVMHYSKNAFAKDP------SKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            |||||...||:...      :||....:||.......:         |..||..:|:|
Frog   217 SVMHYPAWAFSNTTGQNTIVAKPNPNIIIGAGNTMTSL---------DIIKINRLYEC 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	61/209 (29%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	59/203 (29%)
astl2d.5	XP_031756347.1	ZnMc	83..265	CDD:412141	60/203 (30%)
		CUB	268..377	CDD:395345
		CUB	382..493	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010