DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6974 and astl2a

DIOPT Version :9

Sequence 1:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_002934118.2	Gene:	astl2a / 100492493	XenbaseID:	XB-GENE-5966804	Length:	492	Species:	Xenopus tropicalis

Alignment Length:	247	Identity:	76/247 - (30%)
Similarity:	119/247 - (48%)	Gaps:	32/247 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IFAPNLVASEGIESYENYYNEIHIDDEQAEAKTRNALTSPLQRWPGNK-----ILYRISTDYSEQ 73
            ||:..|..::| ....:|..:|.:..|:::...::.|      ||.::     :.||||.||...
Frog    40 IFSQILRTNQG-HGGLHYQGDIDVRVERSDGTCKDCL------WPKSQNGSVLVPYRISADYGVS 97

  Fly    74 EVANVRTAMSSFGEQTCVQFEEIEGAPPAGKRYVSFKKSPNMC----GTRVGYQPLSFGPHEVVL 134
            ::.::..||..|...|||:|     .|.:.:|.....:|.|.|    |...|.|.:|      :|
Frog    98 DIESITDAMLEFSTLTCVRF-----VPRSAERDHVIIRSENGCFSSKGRLGGAQTVS------LL 151

  Fly   135 NEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQIDYDNIPRKYWSQFMAMDQTTTFNVPYDYE 199
            ...|:.. .:||||..|:|||.||.||.|||||:.:...|||.::...| ...::....:.|||.
Frog   152 KPDCVEF-GIIQHELNHVLGLAHENSRMDRDEYITVIETNIPAEFHRDF-EKPESDIVGMEYDYN 214

  Fly   200 SVMHYSKNAFAKDPSKPTIRALIGGKAVEREMGQVRGPSEGDWTKIRLMYKC 251
            |||||...||:......|   |:..:....::||:.|.|..|.:||..:|:|
Frog   215 SVMHYGSGAFSNTGGMST---LVPKRNPNAQLGQLYGLSNLDVSKINRLYEC 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	67/204 (33%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	64/198 (32%)
astl2a	XP_002934118.2	ZnMc	81..263	CDD:412141	65/197 (33%)
		CUB	267..377	CDD:238001
		CUB	380..491	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020