DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sdr and TEK

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_000450.3 Gene:TEK / 7010 HGNCID:11724 Length:1124 Species:Homo sapiens


Alignment Length:740 Identity:157/740 - (21%)
Similarity:243/740 - (32%) Gaps:265/740 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 LKHNRPQSQCPLCGSLSADF--------EFIRNSSERC----WNVNTTQLRPQPPRLKDCPIACG 235
            |.|.:||.    .|..||.:        .|.|....||    |.          |.......||.
Human   178 LPHAQPQD----AGVYSARYIGGNLFTSAFTRLIVRRCEAQKWG----------PECNHLCTACM 228

  Fly   236 LNG-C-DSAGKCCDHNCVTGCYSQNCSLCANYQGRMGCVNQCVASYELN------KRRCIGHREC 292
            .|| | :..|:|.   |..|           :.||. |...|    ||:      |.||.|...|
Human   229 NNGVCHEDTGECI---CPPG-----------FMGRT-CEKAC----ELHTFGRTCKERCSGQEGC 274

  Fly   293 RE--------------LGRIPLIRGYQCVKKC-PGNQKEILVAKGIIHCQVEC---NGDFHVKSA 339
            :.              .|    .:|.||.:.| ||....        .|::.|   ||:.     
Human   275 KSYVFCLPDPYGCSCATG----WKGLQCNEACHPGFYGP--------DCKLRCSCNNGEM----- 322

  Fly   340 ADLEVLQDCVTING--SLTIELTNIKE---KIVDALENALASVKEITGYLKVIHSAQLMSLTFLQ 399
              .:..|.|:...|  .|..|...|:.   ||||..::    ::..:|....|..|....|...:
Human   323 --CDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDH----IEVNSGKFNPICKASGWPLPTNE 381

  Fly   400 NLDAIRGDKLVENKYALYVVNNYHLEH----------IWPPNHLVIIQRGTLFFHLNPRLCYEKI 454
            .:..::.|..|     |:..:..|.:|          |.||:..|.:             |  .:
Human   382 EMTLVKPDGTV-----LHPKDFNHTDHFSVAIFTIHRILPPDSGVWV-------------C--SV 426

  Fly   455 HQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLN-PKVEDLNSTAVRIILDYMDWEGMETLI 518
            :.:.|.::...|||| .|.|             :.|| |.|.|.......|.:....:.|...:.
Human   427 NTVAGMVEKPFNISV-KVLP-------------KPLNAPNVIDTGHNFAVINISSEPYFGDGPIK 477

  Fly   519 GYSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQSRRHVISGLKPYTQYAYFVKTLTRTEYHI 583
            .....||  ||.:           ::.|....|.|:.  ..::.|:|.|:|...|:.:.|.|   
Human   478 SKKLLYK--PVNH-----------YEAWQHIQVTNEI--VTLNYLEPRTEYELCVQLVRRGE--- 524

  Fly   584 QIDAYSKIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNAT---- 644
                 ...|:       |.||.|...:|       :...|||..|.:.|    :....|.|    
Human   525 -----GGEGH-------PGPVRRFTTAS-------IGLPPPRGLNLLPK----SQTTLNLTWQPI 566

  Fly   645 -KEAKDKNYVNVELENAKDIDCECAGVLPYYSGPQPDDEDYYNKEQITYEDALP-NLIYVSRNHD 707
             ..::|..||.||..:.:..|                      ::.|    .:| ||..|..|:.
Human   567 FPSSEDDFYVEVERRSVQKSD----------------------QQNI----KVPGNLTSVLLNNL 605

  Fly   708 YRRKEFEKVINYEHLLSIKKDEEPTRPPTT-------TPAPTNATLAK--ERLAAINY---ENYR 760
            :.|:::  |:...  ::.|...|.:...|.       .|.|.|..::.  ...|.|::   :.|.
Human   606 HPREQY--VVRAR--VNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYS 666

  Fly   761 LNSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQL 825
            ::|              .|||:   |.|..:..  |.|:.| :....::.|:|.|         |
Human   667 ISS--------------ITIRY---KVQGKNED--QHVDVK-IKNATITQYQLKG---------L 702

  Fly   826 EPETHYRITIRACVEGVVNGCSTPA 850
            ||||.|::.|.|  |..: |.|.||
Human   703 EPETAYQVDIFA--ENNI-GSSNPA 724

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032
Furin-like 210..332 CDD:395614 33/151 (22%)
Recep_L_domain 347..461 CDD:460032 24/128 (19%)
FN3 491..578 CDD:214495 18/87 (21%)
TEKNP_000450.3 Ig_Tie2_1 24..118 CDD:463089
EGF_Lam 230..275 CDD:238012 17/63 (27%)
EGF_Lam 314..>342 CDD:238012 7/34 (21%)
IgI_Tie2 348..439 CDD:409556 19/114 (17%)
Ig strand A 348..352 CDD:409556 0/3 (0%)
Ig strand A' 358..362 CDD:409556 0/7 (0%)
Ig strand B 365..374 CDD:409556 2/8 (25%)
Ig strand C 382..387 CDD:409556 0/4 (0%)
Ig strand C' 391..393 CDD:409556 1/6 (17%)
Ig strand D 397..401 CDD:409556 0/3 (0%)
Ig strand E 404..412 CDD:409556 0/7 (0%)
Ig strand F 420..428 CDD:409556 2/22 (9%)
Ig strand G 431..439 CDD:409556 1/7 (14%)
fn3 445..520 CDD:394996 20/102 (20%)
fn3 544..626 CDD:394996 23/115 (20%)
FN3 639..731 CDD:238020 31/118 (26%)
PTKc_Tie2 816..1118 CDD:133219
Blue background indicates that the domain is not in the aligned region.

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