Protein Alignment Sdr and ROS1

DIOPT Version :9

• Sequence 1: NP_001287331.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: XP_011534351.1
• Gene: ROS1 / 6098
• HGNCID: 10261
• Length: 2357
• Species: Homo sapiens
• Alignment Length: 1070
• Identity: 190/1070 - (17%)
• Similarity: 342/1070 - (31%)
• Gaps: 384/1070 - (35%)

  Fly    60 THVVGHVRLAYVDLT--DVSGN------YSLDSLASN---------------------VTEISDY 95
            |.:|.||:|...|:.  .|.|.      ||::|...|                     ..::||.
Human   788 TDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDG 852

  Fly    96 LMVY-----RCTGLISLQSIFPRLRIIRGQELLFD---------------QYSLVVYENR----- 135
            |:.:     :|..|.:        .::|||....|               |.:|:.|..|
Human   853 LLYWLVQDSQCIHLYT--------AVLRGQSSTGDTTITEFAAWSTSEISQNALMYYSGRLFWIN 909

  Fly   136 -----NLRELG------LVELLRI-QSGFIRVESNPL---LCFVETVDWIYLMGNATRQHFSLKH 185
                 ..:|:|      ::|..|. |...|:....||   ..|...|    :..:.....|.::.
Human   910 GFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKV----IPDSVQESSFRIEG 970

  Fly   186 NRPQSQCPLCGSLSADF-------EFIRNS----SER---------------CWNVNTT------ 218
            |....|....|..:.|:       ||..:|    ||:               .:|::.|
Human   971 NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWG 1035

  Fly   219 -------QLR--------PQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQNCSLCANYQGR 268
                   .||        |:.||:...|          :||||:.|.|...:..|.....|
Human  1036 KGPKTSLSLRAPETVPSAPENPRIFILP----------SGKCCNKNEVVVEFRWNKPKHEN---- 1086

  Fly   269 MGCVNQCVASYELNKRRCIGHRECRE---LGRIPLIRGYQCVKKCP----GNQKEILVAKGIIHC 326
             |.:.:....|.:: .:.|.::.|.:   :...|.:..:|.....|    ..|.....:||
Human  1087 -GVLTKFEIFYNIS-NQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKG---- 1145

  Fly   327 QVECNGDFH--VKS-AADLEVLQDCVTINGSLTIEL---------TNIKEKIVDAL----ENALA 375
                .|.:.  ||| .:::......:|:.|:..:.|         |...|:::.|:    :|.:
Human  1146 ----PGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEM- 1205

  Fly   376 SVKEITGY------LKVIH-----SAQLMSLTFLQNLDAIRGDKLVENKY-ALYVVNN------Y 422
                  ||      |.::|     |::|...:.:.::..|..|.:..:.| ||....|      .
Human  1206 ------GYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDV 1264

  Fly   423 HLEH-IWPPNHLVIIQRGT--LFFHLNP---RLCYEKI-----------------HQ-LQGSLKS 463
            .||| :..|..:.|..|.:  :.|.:.|   ||.:.::                 |: ||.:..:
Human  1265 DLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATN 1329

  Fly   464 GEN-------------ISVADVSPNSNGERVICGDAVRSLNPKVEDLNSTAVRIILDYMDWEGME 515
            .:|             :|.|.....||.|:.:...|      |.:::.:         ||.||.:
Human  1330 QQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFA------KAQEIWA---------MDLEGCQ 1379

  Fly   516 -------------------TLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQSRRHVI- 560
                               |:.|...::......:..:|..:.|.|.   ::..|.....||::
Human  1380 CWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGA---IVSQVKALRSRHILA 1441

  Fly   561 --SGLKPYTQYAYF----------VKTLTRTEYHIQID-AYSKIGYFQTLPDRPSPVLRIY---- 608
              |.::|:...|:.          :...|.|...|::. |.:.:.::..  ..|:|...:|
Human  1442 YSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGI--TSPTPTYLVYYAEV 1504

  Fly   609 ----GSSEISSQIL-----------LHWWPPRRPNGVIKNYFV-TAEKYNATKE--AKDKNYV-- 653
                .||::..:||           |..:........:|||:. ..|.....||  .|.||.|
Human  1505 NDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPE 1569

  Fly   654 NVELENAKDIDCECAGVLPYYSGPQPDDEDYYNKEQITYEDALPNLIYVSRNHDYRRKEFE---- 714
            .|:|.|. .:..:.:.::.:....:|:..    ||.:.|:.|:.:|..:... ..|:.||.
Human  1570 AVQLINT-TVRSDTSLIISWRESHKPNGP----KESVRYQLAISHLALIPET-PLRQSEFPNGRL 1628

  Fly   715 ---------------KVI---------NYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAIN 755
                           ||:         ...|.::::....|.:|.:.  .|.|.:|.....|.:|
Human  1629 TLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSL--VPENTSLQFNWKAPLN 1691

  Fly   756 YENYRLNSEKKQRDLQDLDQHKYT-IRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHF 819
            ....|...|        |.:.||. ..|....|....|.|..
Human  1692 VNLIRFWVE--------LQKWKYNEFYHVKTSCSQGPAYVCN----------------------- 1725

  Fly   820 YCLSQLEPETHYRITIRACVEGVVNGCSTP 849
              ::.|:|.|.|.:.:....:...|..|.|
Human  1726 --ITNLQPYTSYNVRVVVVYKTGENSTSLP 1753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	35/181 (19%)
		Furin-like	209..332	CDD:279142	28/165 (17%)
		Recep_L_domain	347..461	CDD:279382	32/168 (19%)
		FN3	491..578	CDD:214495	16/118 (14%)
ROS1	XP_011534351.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870