DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and Alk

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster

Alignment Length:	1020	Identity:	191/1020 - (18%)
Similarity:	293/1020 - (28%)	Gaps:	422/1020 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GHLHPVPNPLPIPISIAVPLILLFLGASSPVLASSDDQTAC--GSLEINKIADLRKLQNCTHVVG 64
            |.||..|.|||.|              :.||....:|..|.  ||...||
  Fly    59 GRLHEQPLPLPQP--------------TLPVATQYEDYEAAPPGSRRDNK--------------- 94

  Fly    65 HVRLAYVDLTDVSGN---YSLDSL-------------------ASNVTEISDYLMVYRCTGLISL 107
             .|||.:.....|||   ..::||                   .|.....|....:.|..||
  Fly    95 -RRLAQMAQRPGSGNGGRRGMESLRKELMNPSVGGPGGGISGGGSGYPSYSATSSIGRIDGL--- 155

  Fly   108 QSIFPRLRIIRGQEL-LFDQYSLVVYENRNLRELGLVELLRIQSGFIRVESN-----------PL 160
                       ||.| ..|:|.            .|.:.||..||...:.:.           ||
  Fly   156 -----------GQGLGSADRYG------------ALYDQLRQPSGMAAMTAGPLGGPYSTRFPPL 197

  Fly   161 LCFVETVDWIYLMGNATRQHFSLKHNRPQSQCPLCGSLSADFE----------------FIRNSS 209
            ...|:.........|:..:.:.||....|:..|..|....:||                .||::|
  Fly   198 YAGVDDQPKRSNRKNSISELYKLKKALNQADEPAGGVTHGNFEGDPQPSSADPLQEIKDRIRDTS 262

  Fly   210 ERCWNVNT----TQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQNCS-LCANYQGRM 269
            .   |.||    |...|......:..:.|.                   :...|| ...||....
  Fly   263 P---NANTYAPHTDATPSSEYEYELGVKCN-------------------FETPCSWTWGNYSDGF 305

  Fly   270 GCVNQCVASYELNKRRCIGHRECRELGRIPLIRGYQCVKKCPGNQKEILVAKGIIHCQVECNGDF 334
                |.:...||:||...|                    ..||
  Fly   306 ----QVITGTELSKRNLTG--------------------LLPG---------------------- 324

  Fly   335 HVKSAADLEVLQDCVTINGSLTIELTNIKEKIVDALENALASVKEITG---YLKVIHSAQLMSLT 396
               .|||                                  |:.:..|   |.:|..|::.::||
  Fly   325 ---PAAD----------------------------------SIDDANGHFLYARVNPSSRPLNLT 352

  Fly   397 ---------------FLQNLDAIRGDKLVENKYALYVVNNYH-LEHIWPPNHLV---IIQRGTLF 442
                           ::...|...|...|       ||...| .|..|.|..::   :.|.....
  Fly   353 SPEFSTTMEKCFLEVYMHQSDMSHGLSRV-------VVELLHTAESSWVPAEILGDNVRQWTRKV 410

  Fly   443 FHLNP-----RLCYEKIHQLQGSLKSG---ENISVADVSPNSNGERVICGDAVRSLNPKV----- 494
            :.|..     |:.:|.:..|:...|..   :|:.:.:..|............|:..:.||
  Fly   411 YRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCSTSQVKCTSSKVPVCIH 475

  Fly   495 --------------EDLNSTAVRIIL--------DYMDW-EGMETLIGYSYHYKEAPVQNVTMYD 536
                          ||...:..:|..        |:..| :..:|.:.:|.|...:|..: |..|
  Fly   476 LPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWRDSGKTTLTWSRHTGSSPTHD-TGPD 539

  Fly   537 GRHGCGH-----DNWLMDVVPNQ----SRRHVISGLKPYTQYAYFV-KTLT-RTEYHIQIDAYSK 590
            |.|...|     ..:.|.|..||    |.::.|.|   :...|..| ||.. ....|...|:
  Fly   540 GDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIG---FASNAIMVSKTFNPPPSVHGNPDS--- 598

  Fly   591 IGYFQTLPDRPSPVLRIY--------GSSEISSQILLH--------WWPPR-------RPNGVIK 632
                   |.|.|.|:|.:        ||..:|...:..        ||..:       |...|:.
  Fly   599 -------PYRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGSDWMRAEYVLP 656

  Fly   633 NYFVTAEKYNATKEAK--DKNYVNVELENAKDIDCECAGV-LPYYSGPQPDDEDY---YNKEQIT 691
            |  :|: ||....||:  .:.|.:|.:::. .:..||.|: :|         ||:   ||
  Fly   657 N--ITS-KYYLQFEARMGMRIYSDVAVDDF-SLSPECFGLNIP---------EDHLGGYN----- 703

  Fly   692 YEDALPNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERL---AA 753
            |.|...||    ::..|  |:||    |.:.|.:            |...|...:...:.   ||
  Fly   704 YWDVRQNL----KSPTY--KDFE----YTNYLEL------------TTCDTRGMIGPSQAQCEAA 746

  Fly   754 INYENYRLNSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQH 818
                 ||             :|:|   .|.|.:        |..||::       |.|:  |.|.
  Fly   747 -----YR-------------EQNK---THVLRE--------VHVVEDQ-------SSYK--GMQK 773

  Fly   819 FYCLSQLEPETHYRITIRACVEGVVNGCSTPAEAVIKTASIQLER 863
            :    ::..|.||.|..:....|:.:|....:...:..|.::|.:
  Fly   774 W----KVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHK 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	26/148 (18%)
		Furin-like	209..332	CDD:279142	19/127 (15%)
		Recep_L_domain	347..461	CDD:279382	21/140 (15%)
		FN3	491..578	CDD:214495	27/125 (22%)
Alk	NP_001261027.1	MAM	288..450	CDD:279023	39/270 (14%)
		MAM	288..447	CDD:99706	39/267 (15%)
		MAM	505..691	CDD:279023	46/203 (23%)
		MAM	505..689	CDD:99706	44/201 (22%)
		PTKc_ALK_LTK	1186..1462	CDD:270632
		TyrKc	1193..1460	CDD:197581
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455352
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930