Protein Alignment Sdr and Ret

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 971
• Identity: 187/971 - (19%)
• Similarity: 302/971 - (31%)
• Gaps: 370/971 - (38%)

  Fly    30 SPVLASSDDQTACGSLEINKIAD----------LRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDS 84
            |.|.|.|.....|..:.::|:.:          ||..|:          ...:..:.:|:.:..|
  Fly   363 SRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQH----------RIFESEEFNGDSAGRS 417

  Fly    85 LASNVTEISDYLMVYRCTGLISLQSIFP-------RLRIIRGQELLFDQYSLVVYENRNLRELGL 142
            |:....:....:.||| :...:.:.:.|       |||.||     ||     :.|:: |...|:
  Fly   418 LSPPTVDYDKDVSVYR-SAASNFRVVQPDSFLDLMRLRSIR-----FD-----IVEDK-LGAFGI 470

  Fly   143 VELLRIQSGFIRVESNPLLCFVETVDWIYLMGNAT---RQHFS--------LKHNRPQ-SQCPLC 195
            ..    .||.:.|::..:|  .|..:.||.: |.|   :|..|        |.|.||: :.|.|
  Fly   471 TS----TSGIVFVKNPQVL--EEAPETIYFL-NVTWIDQQRLSHVRVINVHLVHGRPENTSCEL- 527

  Fly   196 GSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGK---------------- 244
                    .:::.|:.|     .|::.|...::.|.:|.|...|...|.
  Fly   528 --------KVKSRSQTC-----AQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPES 579

  Fly   245 --CCDHNC--------------------VTGCYSQN------------CSLCANYQGRMGCV--- 272
              |.||.|                    :.|.:|.|            | :|.: .|:..|.
  Fly   580 RYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTC-ICED-NGKCSCAPLD 642

  Fly   273 ------------NQCVASYELNKRRCIGHRECRELGRIPL----------IRGYQC-------VK 308
                        |:..|...|..||.....:       ||          :.|::|       |.
  Fly   643 EEPKMKKPRKRKNETEAEPLLGVRRGTPPNQ-------PLQDPMLLGVLNVAGFECDRSCMFFVI 700

  Fly   309 KCP----------------------GNQ------KEILVAKGIIHCQVECNGDF---HVKSAADL 342
            .||                      |.|      |:.|...|        .|||   .::|....
  Fly   701 TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESG--------GGDFALMPLQSGFRF 757

  Fly   343 EVLQDCVTINGSLTIELTNIKEKIVDAL-ENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRG 406
            |        :|....|....|.::...| |.....|  :.|:...|  |.|..:|.:......:|
  Fly   758 E--------SGDAKWEFPREKLQLDTVLGEGEFGQV--LKGFATEI--AGLPGITTVAVKMLKKG 810

  Fly   407 DKLVENKYALYVVNNYHLEHIWPPNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVAD 471
            ...||  |...:.....|:.:..||  ||...|.......|.|..|  :...|||:|...:|
  Fly   811 SNSVE--YMALLSEFQLLQEVSHPN--VIKLLGACTSSEAPLLIIE--YARYGSLRSYLRLS--- 866

  Fly   472 VSPNSNGERVIC-----GDAVRSLNPKVEDLNSTAVRIILDYMDWE---GMETLIGYSYHYKEAP 528
                   .::.|     .|.|..:|          |:::|.:. |:   ||..|......:::..
  Fly   867 -------RKIECAGVDFADGVEPVN----------VKMVLTFA-WQICKGMAYLSELKLVHRDLA 913

  Fly   529 VQNVTMYDGR------HGCGHDNWLMDVVPNQSRRHV-ISGLKPYTQYAYFVKTLTRTEYHIQID 586
            .:||.:.||:      .|...|.:..|....:||..| :..:.|        ::|....|..:.|
  Fly   914 ARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP--------ESLADHVYTSKSD 970

  Fly   587 AYS----------------------------KIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWP 623
            .:|                            |.||..   |||.      ..||....|:...|.
  Fly   971 VWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRM---DRPE------NCSEAVYSIVRTCWA 1026

  Fly   624 PRRPNGVIKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGVL-PYYSGP---------- 677
            . .|||.....|:.:|            :..:...|||.||.|...|. |.|.|.
  Fly  1027 D-EPNGRPSFKFLASE------------FEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELG 1078

  Fly   678 QPDD-EDYYNKEQITY------------EDALPNLIYVSRNHDYRRKEFE-----KVINYEH--- 721
            :|:. :..::..:|.|            |:.:|........:|..|...:     :|:.||:
  Fly  1079 EPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLR 1143

  Fly   722 -LLSIKK-------DEEPTRPPTTTPAP---------------TNATLAKERLAAINYENY 759
             .|:|:|       ....:.||.||..|               ||.:|..:.|.:..:|.:
  Fly  1144 FPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMTNKSLIPDNLDSREFEKH 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	24/121 (20%)
		Furin-like	210..332	CDD:395614	36/231 (16%)
		Recep_L_domain	347..461	CDD:460032	25/114 (22%)
		FN3	491..578	CDD:214495	19/96 (20%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	67/339 (20%)