DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and btl

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	132/680 - (19%)
Similarity:	198/680 - (29%)	Gaps:	297/680 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SSPVLASSDDQT--ACGSLEINKIADLRKLQNCTHVVGHVRLAYVDLTD-------VSGNYSLDS 84
            |:|::....:||  ..|||          :..||        .|.||..       |..|.|||.
  Fly   485 SAPIIVVPQNQTVKVNGSL----------VMKCT--------VYSDLHPTVSWKRVVLKNASLDG 531

  Fly    85 LAS------NVTEISDYLMV------------YRC---TGL-ISLQSIFPRLRIIRGQELLFDQY 127
            |.|      |.|..:|.:::            |.|   :|| .|..|::  ||::....
  Fly   532 LKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVY--LRVVSPLP------ 588

  Fly   128 SLVVYENRNLRELG-------LVELLRIQSGFI-----RVESNPLLCF-VETV-DW-----IYLM 173
            .|.:|...:...||       :|.|..:.|.||     |:....||.. :||| .|     ||..
  Fly   589 PLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRP 653

  Fly   174 GNATRQHFS--------LKHNRPQSQCPLCGSLSAD-------FEFIRNSSERCWNVNTTQLR-- 221
            |.......|        ::..:.::.....|:...|       :||..:|:   |.:...||.
  Fly   654 GGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSN---WEIPRQQLSLG 715

  Fly   222 -------------------PQPPRLKDCPIACGL-----NGCDSA------------GKCCDHNC 250
                               |:.|:|.:..:|..:     ...|.|            ||..:...
  Fly   716 SILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIIN 780

  Fly   251 VTGCYSQNCSL--CANY-----------QGRMGC-----------------VNQCVASYELNK-- 283
            :.||.||...|  ...|           |.|.|.                 ..|.:...||.|
  Fly   781 LLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFA 845

  Fly   284 ------------RRCIGHRECRELGRIPLIRGYQCVKKCPGNQKEILVAKGIIHCQVECNGDFHV 336
                        |||| ||:..                    .:.:||:.|            :|
  Fly   846 FQIARGMEYLASRRCI-HRDLA--------------------ARNVLVSDG------------YV 877

  Fly   337 KSAADLEVLQDC-------VTINGSLTIEL---TNIKEKIVDALENA------------------ 373
            ...||..:.:|.       ...||.|.|:.   .:::||..|:..:.
  Fly   878 MKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPY 942

  Fly   374 --LASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPNHLVII 436
              :.|.:|:..||                :...|.:|..:....:|||    :...|   |....
  Fly   943 PHILSAEELYSYL----------------ITGQRMEKPAKCSLNIYVV----MRQCW---HFESC 984

  Fly   437 QRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLN-PKVEDLNST 500
            .|.|.         .|.:....|.|:.      |..:||         ||...|: |.:|...|:
  Fly   985 ARPTF---------AELVESFDGILQQ------ASSNPN---------DAYLDLSMPMLETPPSS 1025

  Fly   501 AVRIILDYMDWEGMETL-----IGYSYHYK 525
            .     |..|....||.     :.|.|.||
  Fly  1026 G-----DEDDGSDTETFRETSPLRYQYTYK 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	41/162 (25%)
		Furin-like	209..332	CDD:279142	33/204 (16%)
		Recep_L_domain	347..461	CDD:279382	23/143 (16%)
		FN3	491..578	CDD:214495	11/41 (27%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653	27/110 (25%)
		Ig	507..583	CDD:299845	22/85 (26%)
		PKc_like	700..1000	CDD:304357	60/367 (16%)
		TyrKc	712..996	CDD:197581	56/348 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930