DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sdr and INSR

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens


Alignment Length:935 Identity:266/935 - (28%)
Similarity:410/935 - (43%) Gaps:212/935 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PISIAVPLILLFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYV------ 71
            |:.:||..:|  |||:..:....    .|..::| |.:..|.:|:||:.:.||:::..:      
Human    13 PLLVAVAALL--LGAAGHLYPGE----VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE 71

  Fly    72 DLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRN 136
            |..|:|        ...:..|:|||:::|..||.||:.:||.|.:|||..|.|: |:||::|..:
Human    72 DFRDLS--------FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN-YALVIFEMVH 127

  Fly   137 LRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQ-----CP--- 193
            |:||||..|:.|..|.:|:|.|..||::.|:||..::.:....:..|  |:..::     ||   
Human   128 LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVL--NKDDNEECGDICPGTA 190

  Fly   194 ----LCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGC 254
                .|.:...:.:|:    ||||..:..|        |.||..|..:||.:.|.||...|:..|
Human   191 KGKTNCPATVINGQFV----ERCWTHSHCQ--------KVCPTICKSHGCTAEGLCCHSECLGNC 243

  Fly   255 YSQ-----NCSLCANY--QGRMGCVNQCVAS-YELNKRRCIG-------HRECRELGRIP----L 300
             ||     .|..|.|:  .||  ||..|... |.....||:.       |.:|:...|..    :
Human   244 -SQPDDPTKCVACRNFYLDGR--CVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYV 305

  Fly   301 IRGYQCVKKCPG----NQKEILVAKGIIHCQVECN---GDFHVKSAADLEVLQDCVTINGSLTIE 358
            |...:|:.:||.    |...:|....:..|...|:   |:..:.|....:.|:.|..|||||.| 
Human   306 IHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLII- 369

  Fly   359 LTNIK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNN 421
              ||:  ..:...||..|..::||:||||:..|..|:||:|.:.|..|||:.|....|:.|.::|
Human   370 --NIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDN 432

  Fly   422 YHLEHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGD 485
            .:|..:|. ..|.:.|.:|.||||.||:||..:||:::....:.......|::..:||::..|.:
Human   433 QNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN 497

  Fly   486 AVRSLNPKVEDLNSTAVRIILD--YMDWE-----GMETLIGYSYHYKEAPVQNVTMYDGRHGCGH 543
                     |.|..:.:|...|  .:.||     ....|:|:...|||||.||||.:||:..||.
Human   498 ---------ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGS 553

  Fly   544 DNW-LMDVVP------NQSRRH---VISGLKPYTQYAYFVKTL-TRTEYHIQIDAYSKIGYFQTL 597
            ::| ::|:.|      .:|:.|   ::.||||:||||.||||| |.::......|.|.|.|.||.
Human   554 NSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTD 618

  Fly   598 PDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYV--------- 653
            ...||..|.....|..||||:|.|.||..|||.|.:|.|..|:.....|..:.:|.         
Human   619 ATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSR 683

  Fly   654 ---------------NVELENAKDIDCECAGVLPYYSGPQPD-------DEDYYNKEQITYEDAL 696
                           ..|.|::....|.|         |:.|       :|..:.|   |:||.|
Human   684 TWSPPFESEDSQKHNQSEYEDSAGECCSC---------PKTDSQILKELEESSFRK---TFEDYL 736

  Fly   697 PNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRL 761
            .|:::|.|.....              :..:|..|:|...:.....|.|:|...:||  :.|   
Human   737 HNVVFVPRKTSSG--------------TGAEDPRPSRKRRSLGDVGNVTVAVPTVAA--FPN--- 782

  Fly   762 NSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLE 826
                             |...::|.....|...     ||.|.:|.|   .:.|.:||       
Human   783 -----------------TSSTSVPTSPEEHRPF-----EKVVNKESL---VISGLRHF------- 815

  Fly   827 PETHYRITIRACVEGVVNGCSTPAE 851
              |.|||.::||.:      .||.|
Human   816 --TGYRIELQACNQ------DTPEE 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032 44/120 (37%)
Furin-like 210..332 CDD:395614 40/147 (27%)
Recep_L_domain 347..461 CDD:460032 46/116 (40%)
FN3 491..578 CDD:214495 39/104 (38%)
INSRNP_000199.2 Recep_L_domain 52..164 CDD:460032 44/120 (37%)
Furin-like 179..337 CDD:395614 43/172 (25%)
Recep_L_domain 359..472 CDD:460032 46/115 (40%)
FN3 <582..>658 CDD:442628 37/75 (49%)
FN3 622..>665 CDD:238020 19/42 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708 2/21 (10%)
Insulin-binding 733..741 4/7 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 3/33 (9%)
FN3 867..944 CDD:238020
Insulin_TMD 940..987 CDD:465543
PTKc_InsR 1016..1303 CDD:133192
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382
PIK3R1-binding 1361..1364
Blue background indicates that the domain is not in the aligned region.

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