Protein Alignment Sdr and sev

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Alignment Length: 750
• Identity: 140/750 - (18%)
• Similarity: 255/750 - (34%)
• Gaps: 245/750 - (32%)

  Fly     4 LHPVPNPLPIPISIAVPLILLFLGASSPVLASSDDQTACGSLEINKIADLRKLQNCTH------- 61
            ||..|...      |||.:|.   |::..:         |.|::    |.|..:...|
  Fly  1392 LHVAPEVQ------AVPRVLY---ANAEFI---------GELDL----DTRNRRRLVHTASPVEH 1434

  Fly    62 ---VVGHVRLAYVD-----LTDVSGN--YSLDSLASNVTEIS-DYL-----------------MV 98
               :.|..||.:|:     ||.|.|:  ..|..:.:.|..:: |::                 ::
  Fly  1435 LVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEVLALAVDWIQRIVYWAELDATAPQAAII 1499

  Fly    99 YR---CT---GLISLQSIF--PRLRIIR-------GQELLFDQYSLVVYENRNLRELGLVE---- 144
            ||   |.   .::..:.::  ||.|:::       .|.|::.:|......|.:||...|.:
  Fly  1500 YRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRNLTDGSEL 1564

  Fly   145 -------LLRIQSGFIR--------VESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQCPL 194
                   |:|:.:|.:.        |::...||..:....: ...:|.|...:|     ..:..:
  Fly  1565 EWATVQPLIRLHAGSLEPGSETLNLVDNQGKLCVYDVARQL-CTASALRAQLNL-----LGEDSI 1623

  Fly   195 CGSLSADFEF---IRNSSERCWNVN------TTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNC 250
            .|.|:.|..:   ::|.|.|.:...      |.:|.|:..||...                 ||
  Fly  1624 AGQLAQDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQA-----------------HN- 1670

  Fly   251 VTGCYS----QNCSLCANYQGRMGCVNQCVASYELNKRRCIGHRECRELGRIPLIRGYQ-CVKKC 310
                |.    :||.|..:..|.:.....|      .::||:.|        :|:|...: |....
  Fly  1671 ----YQAYPPKNCLLLPSSGGSLLKATDC------EEQRCLLH--------LPMITASEDCPLPI 1717

  Fly   311 PG--NQKEILVAKGIIHCQVECNGDFHVKSAADLEVLQDCVTINGSLTIELTNIKEKIVDALENA 373
            ||  .|..:.:||       |...:.|...   :|.|...: :....::.||::
  Fly  1718 PGVRYQLNLTLAK-------EPGSEEHDHG---MEPLGQWL-LGAGESLNLTDL----------- 1760

  Fly   374 LASVK-EITGYLKVIHSAQL----MSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIW-PPNH 432
            |...: .::|.|...:..:|    :.|..|:.|.|........| :::.|::...||..| ||..
  Fly  1761 LPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRN-FSVRVLSPRELEVSWLPPEQ 1824

  Fly   433 LVIIQRGTLFF--HLNPRLCYEKI------------------HQLQGSLKSGENISV---ADVSP 474
            |   :..::::  |....|..|.:                  |:|.| :|.|...|:   |..:|
  Fly  1825 L---RSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTG-IKPGSGYSLWVQAHATP 1885

  Fly   475 --NSNGERVICGDAVRSLN--PKVEDLNSTAVRIILDYMDWEGMETLIG-YSYHYKEAPVQNVTM 534
              :::.||:    .|||..  |:::.|......:.|   .|.|....:| .....:.:..|....
  Fly  1886 TKSNSSERL----HVRSFAELPELQLLELGPYSLSL---TWAGTPDPLGSLQLECRSSAEQLRRN 1943

  Fly   535 YDGRHGCGHDNWLMDVVPNQSRRHVISGLKPYTQYAY-----FVKTLTRTEYHIQIDAYSKIGYF 594
            ..|.|                .:.|:..|:|.|:|..     :..|.....||...:.|..:|..
  Fly  1944 VAGNH----------------TKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDA 1992

  Fly   595 QTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNG 629
            .:.|.:|.       ...|:.::....|...|.||
  Fly  1993 PSQPGKPQ-------LEHIAEEVFRVTWTAARGNG 2020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	31/183 (17%)
		Furin-like	210..332	CDD:395614	26/134 (19%)
		Recep_L_domain	347..461	CDD:460032	24/139 (17%)
		FN3	491..578	CDD:214495	15/94 (16%)
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	19/95 (20%)
		FN3	1993..2111	CDD:238020	6/34 (18%)
		PTKc_c-ros	2213..2483	CDD:270640