DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sdr and tyro3

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_571507.2 Gene:tyro3 / 30709 ZFINID:ZDB-GENE-990714-13 Length:868 Species:Danio rerio


Alignment Length:390 Identity:78/390 - (20%)
Similarity:136/390 - (34%) Gaps:129/390 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   449 LCYEKIHQLQGSLKSGENISVADV---SPNSNGERVICGDAVRSLNPKVEDLNSTA-VRIILD-- 507
            |..|::..|...|..||..||.:.   |.|::|::|    ||:.|.   .|:||:: :...|.  
Zfish   485 LISERLLTLGRMLGKGEFGSVREAFLKSENNSGQKV----AVKVLK---TDINSSSDIEQCLKEA 542

  Fly   508 -YM-DWE--GMETLIGYSYH---YKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQSRRHVISGLKP 565
             || |:.  .:..|||.|.|   .:..||..|.:...:||..|...||..:          |.:|
Zfish   543 AYMKDFHHPNVIQLIGVSLHRRAQQRLPVPMVILPFMKHGDLHTFLLMSRL----------GDEP 597

  Fly   566 YTQYAYFVKTLTRTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNGV 630
            :|     |......::.:.|                     ..|...:|::.::|.....|...:
Zfish   598 FT-----VSQQILIQFMLDI---------------------ARGMEYLSNKNIIHRDLAARNCML 636

  Fly   631 IKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGVLPYYSGPQPDDEDYYNKEQIT---- 691
            .:|..|....:..:|:                          .|||      |||.:..::    
Zfish   637 NENMSVCVADFGLSKK--------------------------IYSG------DYYRQGSVSKLPV 669

  Fly   692 ---YEDALPNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAA 753
               ..::|.:.:|.:::..:             ...:...|..||..|..|...|:.:       
Zfish   670 KWIALESLADNVYTTQSDVW-------------AFGVTMWEIMTRGQTPYPGVENSEI------- 714

  Fly   754 INYENYRLNSEKKQRDLQDLDQHKYTIRHA----LPKCQNSHASVVQQVE------EKCVAEEPL 808
              || |.:..|:.::. .|.....|.|.|:    :|||:.|...::.|:|      .....:|||
Zfish   715 --YE-YLIKGERLKQP-PDCPADIYEIMHSCWSPVPKCRPSFQHLIDQLELLWAKLNPAPVKEPL 775

  Fly   809  808
            Zfish   776  775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032
Furin-like 210..332 CDD:395614
Recep_L_domain 347..461 CDD:460032 3/11 (27%)
FN3 491..578 CDD:214495 24/96 (25%)
tyro3NP_571507.2 Ig 31..113 CDD:472250
Ig strand B 38..42 CDD:409353
Ig strand C 51..55 CDD:409353
Ig strand E 78..82 CDD:409353
Ig strand F 92..97 CDD:409353
Ig strand G 106..109 CDD:409353
IgI_2_Axl_Tyro3_like 118..198 CDD:409407
Ig strand A 118..121 CDD:409407
Ig strand A' 124..128 CDD:409407
Ig strand B 132..141 CDD:409407
Ig strand C 146..153 CDD:409407
Ig strand C' 155..158 CDD:409407
Ig strand E 163..173 CDD:409407
Ig strand F 176..185 CDD:409407
Ig strand G 189..198 CDD:409407
FN3 203..296 CDD:238020
FN3 304..387 CDD:238020
Protein Kinases, catalytic domain 481..764 CDD:473864 75/377 (20%)
Blue background indicates that the domain is not in the aligned region.

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