Protein Alignment Sdr and ephb4b

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_571492.1
• Gene: ephb4b / 30691
• ZFINID: ZDB-GENE-990415-65
• Length: 976
• Species: Danio rerio
• Alignment Length: 827
• Identity: 153/827 - (18%)
• Similarity: 243/827 - (29%)
• Gaps: 304/827 - (36%)

  Fly   165 ETVDWIYLMGN---ATRQHFSLKHNRPQSQCPLCGSLSADFEFIRNSSERCWNVNTTQLRPQP-- 224
            ||.:..|...:   |:..|.:...| |.|:   ..:::||| .:|...||..||.|.::.|..
Zfish   115 ETFNLYYYQSDEDTASATHPAWMEN-PYSK---VDTVAADF-LLRRGGERKSNVKTVRVGPLSLF 174

  Fly   225 -------------------PRLKDCPIACGLNGC-----------DSAGKCCDHNCVTG-CYSQN 258
                               ...|.||........           .:.|.|.|::..|| |.:..
Zfish   175 GFYLAFQTQGACMALLSVRVFFKKCPAVSRAFSSFPETLPHSLVQQAEGVCVDNSAPTGQCTAPP 239

  Fly   259 CSLC---ANYQGRMGCVNQCVASYE-LNKRRCIGHRECRELGRIPLIRGYQCVKKCPGNQKEILV 319
            ...|   ..:.|.......|...|| ::..||   |.| .||:.....|....:.||.|......
Zfish   240 TMFCGEDGQWVGPPSSTCACKPGYEPVDSDRC---RAC-GLGQYKASVGGSLCRVCPDNSNTHSA 300

  Fly   320 AKGIIHCQVECNGDFHVKSAADLEVLQDCVTINGSLTIELTNIKEKIVDALENALASVKEITGYL 384
            ...:  |  .|...:| ::.:||.                        |:     |..|..:...
Zfish   301 GSSL--C--VCRPGYH-RATSDLP------------------------DS-----ACTKPPSAPR 331

  Fly   385 KVIHSAQ--LMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPNHLVIIQRGTLFFHLNP 447
            .:|:...  :::|.:.:.||  ||.:    ....|.|...|.             ||:|...
Zfish   332 SIIYQINDTVVTLEWSEPLD--RGGR----SDLSYSVECMHC-------------RGSLCVQ--- 374

  Fly   448 RLCYEKIHQLQGSL-KSGENISVADVSPNS---------NGERVICGDAVRSLNPKVEDLNSTAV 502
              |.:.|....|.: .||..:.:..:.|::         ||.     .||...:|....:|.|..
Zfish   375 --CADSITYRPGQMGVSGRRVIIRGLLPHTTYTFTVLAQNGV-----SAVSHTSPASSSVNITTS 432

  Fly   503 RIILDYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQSR--------RHV 559
            |.:                    ..||..:............:|   .||.|::        |:.
Zfish   433 RDV--------------------AVPVSGIRRIKASESSVSISW---TVPPQTQHSIQDYQLRYS 474

  Fly   560 ISGLKPYTQY------AYFVKTLTR-TEYHIQIDAYSKIGY--------FQTLPDRPSPVLRIYG 609
            :.|.....||      :..:..|:| ::|.:|:.|.:..||        ..||||
Zfish   475 LKGQDDGWQYVSSRSSSVVLNDLSRASQYQVQVRARTAAGYGHFSSAVSISTLPD---------- 529

  Fly   610 SSEISSQILLHWWPPRRPNGV---------IKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDC 665
            ..|..|:::|        .||         |....|....:..:...:|
Zfish   530 DEESPSRLML--------TGVLVAIGLLILIAVVIVAVFCFRRSTRRRD---------------- 570

  Fly   666 ECAGVLPYYSGPQPDDEDYYNKEQ--------ITYEDALPNLIYVSRNHDYRRKEFEKVIN---- 718
                       |.||....:...|        .||||  ||...         :||.|.|:
Zfish   571 -----------PDPDKSGQFLMGQGIKVYIDPFTYED--PNEAV---------REFAKEIDVSFV 613

  Fly   719 -YEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAI-----NYENYRLNSEKKQRDLQDLDQHK 777
             .|.::...:..|..|.....|.      .||...||     .|      ::|::||.
Zfish   614 KIEEVIGAGEFGEVCRGRLKVPG------KKENYVAIKTLKGGY------TDKQRRDF------- 659

  Fly   778 YTIRHALPKCQNSHASVVQQVEEKCVAEEP---LSGY-ELPGTQHFYCLS--QLEPETHYRITIR 836
              :..|....|..|.::: .:|....|..|   |:.| |......|..|:  |..|     |.:.
Zfish   660 --LSEASIMGQFQHPNII-HLEGVITASCPVMILTEYMENGALDSFLRLNDGQFTP-----IQLV 716

  Fly   837 ACVEGVVNGCSTPAE------------------AVIKTASIQLERFI 865
            ..:.|:.:|....:|                  .|.|.:...|.||:
Zfish   717 GMLRGIASGMKYLSEMSFVHRDLAARNILVNSNLVCKVSDFGLSRFL 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	3/7 (43%)
		Furin-like	210..332	CDD:395614	32/158 (20%)
		Recep_L_domain	347..461	CDD:460032	18/115 (16%)
		FN3	491..578	CDD:214495	15/100 (15%)
ephb4b	NP_571492.1	EphR_LBD	25..198	CDD:470656	18/87 (21%)
		FN3	327..431	CDD:238020	24/132 (18%)
		FN3	438..526	CDD:238020	17/90 (19%)
		EphA2_TM	540..610	CDD:464211	19/107 (18%)
		PTKc_EphR_B	608..876	CDD:173638	35/183 (19%)
		SAM_superfamily	906..969	CDD:472832