Protein Alignment Sdr and EPHA10

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_001092909.1
• Gene: EPHA10 / 284656
• HGNCID: 19987
• Length: 1008
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 50/245 - (20%)
• Similarity: 84/245 - (34%)
• Gaps: 74/245 - (30%)

  Fly   169 WIYLMGNATRQHFSL-KHNRPQSQCPLCGSLSADFE-------FIRNSSERCW-NVNTTQLRPQP 224
            |..|..|...:...: :|:||.....:|..|..:.:       ..|...:|.: .:..|
Human    50 WTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIFVELQFT------ 108

  Fly   225 PRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQNCSLCANYQGRMG----------CVNQCVASY 279
              |:||....|     :||.|.:...|  .|.:..:.....:.|:|          ..::.....
Human   109 --LRDCSSIPG-----AAGTCKETFNV--YYLETEADLGRGRPRLGGSRPRKIDTIAADESFTQG 164

  Fly   280 ELNKRRCIGHRECRELGRIPLIR-----GYQCVKKCPGNQKEILVAKGIIHCQVECNGDFHVKSA 339
            :|.:|:...:.|.||:|  ||.|     .:|.|..|..     ||:..:.:.|  |.
Human   165 DLGERKMKLNTEVREIG--PLSRRGFHLAFQDVGACVA-----LVSVRVYYKQ--CR-------- 212

  Fly   340 ADLEVLQDCVTINGSLTIELTNIKEKIVDALENALASVKEITGYLKVIHS 389
                     .|:.|..|...|        |.|:|.:::.|:.|.. |.||
Human   213 ---------ATVRGLATFPAT--------AAESAFSTLVEVAGTC-VAHS 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	1/3 (33%)
		Furin-like	210..332	CDD:395614	29/137 (21%)
		Recep_L_domain	347..461	CDD:460032	12/43 (28%)
		FN3	491..578	CDD:214495
EPHA10	NP_001092909.1	EphR_LBD_A10	35..210	CDD:198455	36/181 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..342
		fn3	339..431	CDD:394996
		FN3	451..531	CDD:214495
		EphA2_TM	569..642	CDD:464211
		PTKc_EphR_A10	639..904	CDD:133195
		SAM_superfamily	929..998	CDD:472832