DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sdr and Igf1r

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:XP_008757722.1 Gene:Igf1r / 25718 RGDID:2869 Length:1372 Species:Rattus norvegicus


Alignment Length:927 Identity:266/927 - (28%)
Similarity:412/927 - (44%) Gaps:209/927 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 LLFLGASSPVLASSDDQTACG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDSL 85
            |:||.|:..:..:|.:  .|| .::| |....|::|:|||.:.|.:.:..:...:...:|....|
  Rat    16 LVFLSAALSLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKL 78

  Fly    86 ASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQS 150
                |.|::||:::|..||.||..:||.|.:|||.:|.:: |:||::|..||:::||..|..|..
  Rat    79 ----TVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN-YALVIFEMTNLKDIGLYNLRNITR 138

  Fly   151 GFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-----------PLCGSLSADFEF 204
            |.||:|.|..||::.|:||..::...:..:  :..|:|..:|           |:|...:.:.|:
  Rat   139 GAIRIEKNADLCYLSTIDWSLILDAVSNNY--IVGNKPPKECGDLCPGTLEEKPMCEKTTINNEY 201

  Fly   205 IRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----CSLCANY 265
                :.|||..|..|        |.||..||...|....:||...|:..|::.:    |..|.:|
  Rat   202 ----NYRCWTTNRCQ--------KMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHY 254

  Fly   266 QGRMGCVNQC-VASYELNKRRCIGHRECRELGRIP----------LIRGYQCVKKCPG----NQK 315
            ..:..||..| ..:|.....||:....|   ..||          :|...:|:::||.    |..
  Rat   255 YYKGVCVPACPPGTYRFEGWRCVDRDFC---ANIPNAESSDSDGFVIHDGECMQECPSGFIRNST 316

  Fly   316 EILVAKGIIHCQVECN---GDFHVK-----SAADLEVLQDCVTINGSLTIELTNIK--EKIVDAL 370
            :.:..   |.|:..|.   ||...|     |....::||.|..:.|:|   |.||:  ..|...|
  Rat   317 QSMYC---IPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNL---LINIRRGNNIASEL 375

  Fly   371 ENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPNHL-V 434
            ||.:..::.:|||:|:.||..|:||:||:||..|.|::.:|..|:.||::|.:|:.:|..||. :
  Rat   376 ENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNL 440

  Fly   435 IIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVIC-GDAVRSLNPKVEDLN 498
            .::.|.::|..||:||..:|::::....:....|..|::..:||||..| .|.:|        ..
  Rat   441 TVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLR--------FT 497

  Fly   499 STAV---RIIL--------DYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLM---D 549
            ||..   |||:        ||.|      ||.::.:|||||.:|||.|||:..||.::|.|   |
  Rat   498 STTTWKNRIIITWHRYRPPDYRD------LISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVD 556

  Fly   550 VVPNQSRRH--VISGLKPYTQYAYFVK--TLTRTEY-HIQIDAYSKIGYFQTLPDRPSPVLRIYG 609
            :.||:....  ::.||||:||||.:||  |||..|. ||: .|.|:|.|.:|....||..|.:..
  Rat   557 LPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIR-GAKSEILYIRTNASVPSIPLDVLS 620

  Fly   610 SSEISSQILLHWWPPRRPNGVIK------------------NYFVTAEKYNATKEAKDKNYVNVE 656
            :|..|||:::.|.||..|||.:.                  ||...|:|....|.|.....|...
  Rat   621 ASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKADKIPIRKYADGTIDVEEV 685

  Fly   657 LENAK-DIDCECAGVL-PYYSGPQPDDEDYYNKEQITY----EDALPNLIYVSRNHDYRRKEFEK 715
            .||.| ::   |.|.. |..:.|:.:.|....||:..|    |:.|.|.|:|.|....||     
  Rat   686 TENPKTEV---CGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRR----- 742

  Fly   716 VINYEHLLSIKKDEEPTRPPTTTPAPT-NATLAKERLAAINYENYRLNSEKKQRDLQDLDQHKYT 779
                 .:|.:......:|...||.|.| |.|..:|  ....|..:....:.|:|.:         
  Rat   743 -----DVLQVANTTMSSRSRNTTVADTYNITDPEE--FETEYPFFESRVDNKERTV--------- 791

  Fly   780 IRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLEPETHYRITIRAC-VEGVV 843
                                                      :|.|.|.|.|||.|.:| .|...
  Rat   792 ------------------------------------------ISNLRPFTLYRIDIHSCNHEAEK 814

  Fly   844 NGCST---------PAE 851
            .|||.         |||
  Rat   815 LGCSASNFVFARTMPAE 831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032 42/114 (37%)
Furin-like 210..332 CDD:395614 35/143 (24%)
Recep_L_domain 347..461 CDD:460032 41/116 (35%)
FN3 491..578 CDD:214495 40/104 (38%)
Igf1rXP_008757722.1 Recep_L_domain 51..161 CDD:460032 42/114 (37%)
Furin-like 175..330 CDD:395614 39/172 (23%)
Recep_L_domain 353..468 CDD:460032 41/117 (35%)
FN3 494..607 CDD:238020 49/127 (39%)
FN3 612..>656 CDD:238020 13/43 (30%)
FN3 837..926 CDD:238020
PTKc_InsR_like 994..1271 CDD:173625
Blue background indicates that the domain is not in the aligned region.

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