DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and Insr

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_058767.2	Gene:	Insr / 24954	RGDID:	2917	Length:	1384	Species:	Rattus norvegicus

Alignment Length:	946	Identity:	262/946 - (27%)
Similarity:	410/946 - (43%)	Gaps:	217/946 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AVPLIL----LFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYV------ 71
            ||||::    |.:|.:..:....    .|..::| |.:..|.:|:||:.:.||:::..:
  Rat    11 AVPLLMAVAALLVGTAGHLYPGE----VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE 71

  Fly    72 DLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRN 136
            |..|:|        ...:..|:|||:::|..||.||:.:||.|.:|||..|.|: |:||::|..:
  Rat    72 DFRDLS--------FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN-YALVIFEMVH 127

  Fly   137 LRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQ-----CP--- 193
            |:||||..|:.|..|.:|:|.|..||::.|:||..::.:....:..|  |:..::     ||
  Rat   128 LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVL--NKDDNEECGDVCPGTA 190

  Fly   194 ----LCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGC 254
                .|.:...:.:|:    ||||..:..|        |.||..|..:||.:.|.||...|:..|
  Rat   191 KGKTNCPATVINGQFV----ERCWTHSHCQ--------KVCPTICKSHGCTAEGLCCHKECLGNC 243

  Fly   255 YSQN----CSLCANYQGRMGCVNQCVAS-YELNKRRCIGHRECREL------GRIP-----LIRG 303
            ...:    |..|.|:.....||..|... |.....||:....|::|      .|.|     :|..
  Rat   244 SEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHYKCRNSRKPGCHQYVIHN 308

  Fly   304 YQCVKKCPG----NQKEILVAKGIIHCQVEC---NGDFHVKSAADLEVLQDCVTINGSLTIELTN 361
            .:|:.:||.    |...::....:..|...|   .|:..:.|....:.|:.|..|||||.|   |
  Rat   309 NKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLII---N 370

  Fly   362 IK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHL 424
            |:  ..:...||..|..::||:|:||:..|..|:||:|.:.|..|||:.|....|:.|.::|.:|
  Rat   371 IRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNL 435

  Fly   425 EHIWPPN-HLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVR 488
            ..:|..| |.:.|.:|.||||.||:||..:||:::....:.......|::..:||::..|.:
  Rat   436 RQLWDWNKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN--- 497

  Fly   489 SLNPKVEDLNSTAVRIILD--YMDWE-----GMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNW 546
                  |.|..:.:|...|  .:.||     ....|:|:...|||||.||||.:||:..||.::|
  Rat   498 ------ELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSW 556

  Fly   547 -LMDVVP--------NQSRRH---VISGLKPYTQYAYFVKTL-TRTEYHIQIDAYSKIGYFQTLP 598
             ::|:.|        :|:..|   ::.||||:||||.||||| |.::......|.|.|.|.||..
  Rat   557 TVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDA 621

  Fly   599 DRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYV---------- 653
            ..||..|.....|..||||:|.|.||..|||.|.:|.|..|:.....|..:.:|.
  Rat   622 TNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRT 686

  Fly   654 --------NVELENAKDID------CECAGVLPYYSGPQPD-------DEDYYNKEQITYEDALP 697
                    :.:..|..:.|      |.|         |:.|       :|..:.|   |:||.|.
  Rat   687 WSPPFESDDSQKHNQSEYDDSASECCSC---------PKTDSQILKELEESSFRK---TFEDYLH 739

  Fly   698 NLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRLN 762
            |:::|.|.                 .|.....|.|||
  Rat   740 NVVFVPRK-----------------TSSGNGAEDTRP---------------------------- 759

  Fly   763 SEKKQRDLQDLDQHKYTIRHALPKCQNSHASVV------QQVEEKCVAEEPLSGYELPGTQHFYC 821
             .:|:|.|:::.....| ...||...|..:::.      .:..||.|.:|.|   .:.|.:||
  Rat   760 -SRKRRSLEEVGNVTAT-TPTLPDFPNISSTIAPTSHEEHRPFEKVVNKESL---VISGLRHF-- 817

  Fly   822 LSQLEPETHYRITIRAC-VEGVVNGCSTPAEAVIKT 856
                   |.|||.::|| .:.....||..|....:|
  Rat   818 -------TGYRIELQACNQDSPEERCSVAAYVSART 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	44/120 (37%)
		Furin-like	209..332	CDD:279142	36/145 (25%)
		Recep_L_domain	347..461	CDD:279382	46/116 (40%)
		FN3	491..578	CDD:214495	39/106 (37%)
Insr	NP_058767.2	Recep_L_domain	52..164	CDD:279382	44/120 (37%)
		Furin-like	179..337	CDD:279142	39/169 (23%)
		FU	234..281	CDD:238021	12/46 (26%)
		Recep_L_domain	359..472	CDD:279382	46/115 (40%)
		FN3	624..>667	CDD:238020	19/42 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..710		2/21 (10%)
		Insulin-binding. /evidence=ECO:0000250	735..743		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..784		11/65 (17%)
		FN3	869..946	CDD:238020
		Important for interaction with IRS1, SHC1 and STAT5B	998..1001
		PTKc_InsR	1018..1305	CDD:133192
		Pkinase_Tyr	1025..1292	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1384
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8051
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920