DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and igf1ra

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_694500.1	Gene:	igf1ra / 245701	ZFINID:	ZDB-GENE-020503-1	Length:	1405	Species:	Danio rerio

Alignment Length:	939	Identity:	267/939 - (28%)
Similarity:	421/939 - (44%)	Gaps:	205/939 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LFLGASSPVLASSDDQTACGSLEI--------NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNY 80
            ||.|   |.|..|.....|...|:        |.|.:.:||:|||.|.|::::..:.  |.:.|.
Zfish    12 LFWG---PALFLSTICLRCARGEVCGPHIDIRNDITEFKKLENCTVVEGYLQILLIG--DKNNNL 71

  Fly    81 SLDSLAS----NVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELG 141
            :.:...:    .:|.::||::::|.:||.||..:||.|.:|||:.|.:: |:||::|..:|:::|
Zfish    72 NQEHFRTLSFPKLTMVTDYILLFRVSGLDSLSVLFPNLNVIRGRNLFYN-YALVIFEMTSLKDIG 135

  Fly   142 LVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-PLCGSLSAD---- 201
            |..|..|..|.||:|.||.||::::|||..||......:  :..|:...:| .:|..::.|
Zfish   136 LYNLRNITRGAIRIEKNPELCYLDSVDWSLLMDAEFNNY--IAGNKQTKECGDVCPGINKDRPHC 198

  Fly   202 --FEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----CS 260
              ..|..|.|.|||..|..|        |.||..|....|..||:||...|:..|...:    |:
Zfish   199 IRTSFNDNYSYRCWTSNHCQ--------KVCPKECEKRACTDAGQCCHPQCLGSCTEADNDKACA 255

  Fly   261 LCANYQGRMGCVNQCVA-SYELNKRRCIGHRECRELGRIP-----LIRGYQCVKKCPG--NQKEI 317
            .|.:|.....||..|.. :|:....|||....|..: .:|     :|...:|:..||.  .:.|.
Zfish   256 ACQHYFHEDRCVEACPPDTYKFEGWRCITMEMCARV-HLPSEVDFVIHNGECMPDCPPGFTRNET 319

  Fly   318 L-----VAKGIIHCQVECNGDFHVKSAADLEVLQDCVTINGSLTIELTNIK--EKIVDALENALA 375
            |     ...|:  |...|... .:.|....:.||.|..|.|:|.|   ||:  ..|...||:.:.
Zfish   320 LSMFCSACDGL--CDKVCESK-TIDSVDAAQSLQGCTVIKGNLQI---NIRRGNNIASELESFMG 378

  Fly   376 SVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWP-PNHLVIIQRG 439
            .::.:|||:::.|:..|.||:||::|..|.|::||:|.||.:.|:|::|:::|. ..|.:.|:.|
Zfish   379 LIQTVTGYVRIKHTHTLGSLSFLKSLRYIVGEELVDNTYAFHAVDNHNLQYLWDWTQHNLTIRTG 443

  Fly   440 TLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLNPKVEDLNSTAVRI 504
            .|:|..||:||..:|.::.......|.::..||  .|||||..|...:  |..:.....||.:::
Zfish   444 KLYFRFNPKLCMSEIRKMWEKTSVREKMAEDDV--RSNGERASCESYI--LKFRSNHTQSTRIKL 504

  Fly   505 IL------DYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNW-LMDV-VPNQSRRH--- 558
            ..      ||.|      ||.:..:|||||.||:|.:||:.|||.::| ::|| :|.:....
Zfish   505 TWERYRPPDYRD------LISFIVYYKEAPFQNITEFDGQDGCGSNSWNMVDVDLPQEKSIDPGV 563

  Fly   559 VISGLKPYTQYAYFVK--TLTRTEYHIQIDAYSKIGYFQTLPDRPSPVL--RIYGSSEISSQILL 619
            ::|.|||:||||.|||  ||...:.|:. .|.|::.|.:|....||..|  |.|.:|  ||.:::
Zfish   564 LLSPLKPWTQYAIFVKAVTLVVEDKHVG-GAKSEVVYIRTNASAPSMPLDARAYANS--SSSLMV 625

  Fly   620 HWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGVLPYYSGPQPDDEDY 684
            .|.||..||| .|.::|...:                                    .|.:|.:.
Zfish   626 KWSPPIAPNG-NKTFYVLRWQ------------------------------------QQAEDGEL 653

  Fly   685 YNKEQITYEDALPNLIYVSRNHDYRRKEFEKV---INYEHLLSIKKDEEPTRPPTT------TPA 740
            |                   .|:|..||. |:   |:...|..::.:.:||:....      .|.
Zfish   654 Y-------------------QHNYCSKEL-KIPIRISATSLSDMEGETKPTKSDVAGGEKGCCPC 698

  Fly   741 P-TNATL---AKERLAAINYENYRLNS-------EKKQRDLQDLDQHKYTIRHALPKCQNSHASV 794
            | |...|   |::|.....:||:..||       ::|:|||..:                :::::
Zfish   699 PKTKEDLKAEAEDRSYRKVFENFLHNSIFTPRPPDRKRRDLMGV----------------ANSTL 747

  Fly   795 VQQVEEK-CVAEEPLSGYELP--------GTQH--FYCLSQLEPETHYRITIRACVEGVVNGCST 848
            |..|... .|.|..::..|||        |..|  |..:..|.|.|.|||.|.|| ...|:.||.
Zfish   748 VSGVSRNISVLESNITQPELPEKEYPFSEGKVHTEFMEIHNLRPFTVYRIDIHAC-NYEVHRCSA 811

  Fly   849 PAEAVIKT----------ASIQLERFIKG 867
            .|....:|          .|:..||..||
Zfish   812 AAFVFSRTKPADKADDIPGSVTQERDEKG 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	42/118 (36%)
		Furin-like	209..332	CDD:279142	38/139 (27%)
		Recep_L_domain	347..461	CDD:279382	41/116 (35%)
		FN3	491..578	CDD:214495	37/99 (37%)
igf1ra	NP_694500.1	Recep_L_domain	51..167	CDD:279382	42/118 (36%)
		Furin-like	182..333	CDD:279142	42/161 (26%)
		FU	235..275	CDD:214589	10/39 (26%)
		Recep_L_domain	351..465	CDD:279382	41/116 (35%)
		FN3	497..602	CDD:238020	41/111 (37%)
		FN3	607..>651	CDD:238020	17/82 (21%)
		FN3	844..921	CDD:238020
		PTKc_IGF-1R	990..1266	CDD:133193
		Pkinase_Tyr	997..1264	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8342
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820