DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sdr and insrb

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_001116701.1 Gene:insrb / 245700 ZFINID:ZDB-GENE-020503-4 Length:1348 Species:Danio rerio


Alignment Length:899 Identity:251/899 - (27%)
Similarity:386/899 - (42%) Gaps:194/899 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 CGSLEINKIA-DLRKLQNCTHVVGHVRLAYVDLT---DVSGNYSLDSLASNVTEISDYLMVYRCT 102
            |.|.:|..|| :||.|:|||.:.||:::..:..|   |..| .|...|..    ::|||:::|..
Zfish    28 CPSTDIRNIATNLRVLENCTVIEGHLKILLMFKTTQEDFRG-LSFPKLVM----VTDYLLIFRVY 87

  Fly   103 GLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQSGFIRVESNPLLCFVETV 167
            ||.||.|:||.|.:|||..|.|: |:||::|...::|:||..|..|..|.:|:|.||.||::.|:
Zfish    88 GLESLGSLFPNLTVIRGSNLFFN-YALVMFEMIQMKEIGLHSLTNITRGAVRIEKNPNLCYLSTL 151

  Fly   168 DWIYLMGNATRQHFSLKHNRPQSQC------PLCGSLSADFEFIR-NSSERCWNVNTTQLRPQPP 225
            ||..::.:....:  :..|:...:|      .:.|::|.....|. |..|||||.|..|      
Zfish   152 DWSKILDSVEDNY--IVANKDDLECGNICPGTIAGTISCKQTTINGNFGERCWNQNHCQ------ 208

  Fly   226 RLKDCPIACGLNGCDSAGKCCDHNCVTGC----YSQNCSLCANYQGRMGCVNQCVASYELNKR-R 285
              :.||..|....|.|..:||...|:.||    .|..|..|.|:.....||::|...|...|. |
Zfish   209 --RICPSECVHGACTSHKECCHEQCLGGCSVPGNSTKCVACRNFLYGEACVDRCPPGYYTFKSWR 271

  Fly   286 CIG-------HRECRELG---RIPLIRGYQCVKKCPG-----NQKEILVAKGIIHCQVECNGDFH 335
            |:.       |.:|::..   ...:|....|:.:||.     |...:........|...|.|...
Zfish   272 CVSLQFCQDLHNQCKDKSGDCHAYVIHNGACIPECPSGYTTVNSTSLTCMPCTGRCPKVCTGVQT 336

  Fly   336 VKSAADLEVLQDCVTINGSLTIELTNIKEKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQN 400
            |.|....:.|:.|..:||||.|:::. ...|...||::|..::||||||.:..:..|:||:||:.
Zfish   337 VDSVTAAQALRGCTVLNGSLIIKISG-GNSIAAELESSLGQLEEITGYLTIRRAYALVSLSFLRK 400

  Fly   401 LDAIRGDKLVENKYALYVVNNYHLEHIWPPN-HLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSG 464
            |..|||:.|....|:.:.::|.:|..:|..| |.:.|.:|.:.|..|.:||..:|.:::.:  :|
Zfish   401 LHLIRGETLDGGNYSFHAMDNQNLRQLWDWNKHNLTILKGRMKFIQNGKLCKSEILRMEQA--TG 463

  Fly   465 ENISVADVSPNSNGERVICGDAVRSLNPKVEDLNSTAVRIILD--YMDWEG-----METLIGYSY 522
            ....:.|:|  :..::..|...:         |..|.:|.:.|  .:.||.     ...|:|:..
Zfish   464 TKNRMNDIS--NEKDQSYCESHI---------LKFTQIRTMSDKILIRWESFWPSDFRDLLGFMV 517

  Fly   523 HYKEAPVQNVTMYDGRHGCGHDNW-LMDVVPNQ--------SRRHVISGLKPYTQYAYFVKT-LT 577
            .|||||.:|||.|||:..||.::| :.||.|.|        ...::|..|||:||||..||. |.
Zfish   518 LYKEAPHRNVTEYDGQDACGSNSWAIADVEPPQRPSEGKEVEPGYLIMPLKPWTQYAVMVKAQLA 582

  Fly   578 RTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYF------- 635
            .:|.|....|.::|.|.:|...|||..|..:..|..||||:|.|.||..|||.|.:|.       
Zfish   583 ASEDHQVRGAKTEIIYVRTNATRPSVPLDPHSWSNSSSQIILKWKPPSDPNGNITHYIIYCQKQS 647

  Fly   636 --VTAEKYNATKEA--------------KDKNYVNVELENAKDIDCECAGVLPYYSGPQPDDEDY 684
              :|..|::..::.              :|:.....|:.:.|...|.|           |..|..
Zfish   648 EDITHYKFDYCQQGMKVPSHTPTHHDVEEDQKLNQTEVPDQKGHCCAC-----------PKTEMQ 701

  Fly   685 YNKE------QITYEDALPNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRP-----PTTT 738
            ..||      :.|:|:.|.|.::..|.|  ||:....|.|            .|.|     ||..
Zfish   702 LKKEAEETEFRKTFENYLHNEVFEPRPH--RRRRSVGVAN------------ATLPNFGTTPTII 752

  Fly   739 PAPTNATLAKERLAAINYENYRLNSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCV 803
            |               |:....:..|:|.|.:             :.|..:..|.|:..:     
Zfish   753 P---------------NFPTTSIPEEEKSRKM-------------VFKASSKEAMVISNL----- 784

  Fly   804 AEEPLSGYELPGTQHFYCLSQLEPETHYRITIRACVEGVVNG-CSTPAEAVIKT 856
                         .||         |.|:|.|.||.:....| ||.|.....:|
Zfish   785 -------------LHF---------TSYQIEIHACNDPTDPGRCSMPTYVKART 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032 46/117 (39%)
Furin-like 210..332 CDD:395614 37/141 (26%)
Recep_L_domain 347..461 CDD:460032 39/114 (34%)
FN3 491..578 CDD:214495 37/103 (36%)
insrbNP_001116701.1 Recep_L_domain 45..157 CDD:460032 46/117 (39%)
Furin-like 173..329 CDD:395614 41/163 (25%)
Recep_L_domain 348..463 CDD:460032 39/117 (33%)
FN3 <567..>642 CDD:442628 34/74 (46%)
FN3 606..>649 CDD:238020 17/42 (40%)
FN3 838..919 CDD:238020
Insulin_TMD 916..958 CDD:465543
PTKc_InsR 982..1269 CDD:133192
Blue background indicates that the domain is not in the aligned region.

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