DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and insra

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_005171317.1	Gene:	insra / 245699	ZFINID:	ZDB-GENE-020503-3	Length:	1362	Species:	Danio rerio

Alignment Length:	893	Identity:	258/893 - (28%)
Similarity:	399/893 - (44%)	Gaps:	176/893 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CGSLEI-NKIADLRKLQNCTHVVGHVRLAYVDLT---DVSG-NYSLDSLASNVTEISDYLMVYRC 101
            |.|.:| |.:.:||.|:|||.:.||:::..:..|   |..| :|      ..:|.::|||:::|.
Zfish    36 CSSKDIRNNVTNLRVLENCTVIEGHLKILLMFTTKPEDFRGLSY------PKLTVVTDYLLLFRV 94

  Fly   102 TGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQSGFIRVESNPLLCFVET 166
            .||.||..:||.|.::||..|.|: |:||::|...|:|:||..|:.|..|.:|||.||.||::.|
Zfish    95 YGLESLSDLFPNLTVVRGNNLFFN-YALVLFEMLQLKEIGLHSLMNITRGAVRVEKNPDLCYLST 158

  Fly   167 VDWIYLMGNATRQHF-SLKHNRP-----------QSQCPLCGSLSADFEFIRNSSERCWNVNTTQ 219
            :||..::.:....:. :.|::|.           ::.|||. :::.||      ||||||....|
Zfish   159 LDWSMILDSVEDNYIVANKNDRECGDICPGTVLGKTTCPLT-TINGDF------SERCWNQKYCQ 216

  Fly   220 LRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCY----SQNCSLCANYQGRMGCVNQCV-ASY 279
                    :.||.:|....|....:||...|:.||.    |..|..|.|:.....||.:|. ..|
Zfish   217 --------RMCPSSCKHRACTKDSQCCHDQCLGGCLEPHSSNKCVACRNFMHNNMCVEKCPHGFY 273

  Fly   280 ELNKRRCIGHRECREL------GRIP----LIRGYQCVKKCPGNQKEI-------LVAKGIIHCQ 327
            .....||:....|:||      |:..    :|....|:.:||.....:       ....|:  |.
Zfish   274 TFKGWRCVSFSFCQELHNKCKQGKGDCHEYVIHNGACIPECPSGYTTVNSTTLNCTPCAGL--CP 336

  Fly   328 VECNGDFHVKSAADLEVLQDCVTINGSLTIELTNIK--EKIVDALENALASVKEITGYLKVIHSA 390
            ..|.|...|.|....:.|:.|..|||||.|   ||:  ..|...||..|..::||||||.|.||.
Zfish   337 KVCMGLKTVDSVTAAQALRGCTVINGSLVI---NIRGGNNIAAELEANLGQLEEITGYLTVRHSY 398

  Fly   391 QLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWP-PNHLVIIQRGTLFFHLNPRLCYEKI 454
            .|:||:||:.|..|.|:......|:.|.::|.:|..:|. ..|.:.||:|.:|||.|.:||..:|
Zfish   399 ALVSLSFLRKLRIIHGETQEVGNYSFYALDNQNLRQLWDWSKHNLTIQQGRMFFHHNSKLCMSEI 463

  Fly   455 HQLQGSLKSGENISVADVSPNSNGERVICGDAVRSLNPKVEDLNSTAVRIILDYMDWEG-----M 514
            .:::....:....:..|:...:||::..|...|.    |...:::.:.:||:   .||.     .
Zfish   464 RRMEEVTGTKNRQTKNDIVSKTNGDQASCESKVL----KFTRISTLSDKIII---KWEAFWPPDF 521

  Fly   515 ETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLM-DVVP----NQSRRH----VISGLKPYTQYA 570
            ..|:|:...|||||.:|||.:||:..||.::|:: ||.|    .:.:.|    :|..|||:||||
Zfish   522 RDLLGFMVLYKEAPYKNVTEFDGQDACGSNSWVIADVDPPPRATEGKEHEPGYLIFPLKPWTQYA 586

  Fly   571 YFVKT-LTRTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNY 634
            ..||| |:.::.|....|.|:|.|.:|...:||..|....||..||||:|.|.||..|||.|.:|
Zfish   587 IMVKTQLSASDEHQVHGAKSEIIYVRTNATKPSVPLDPISSSNSSSQIILKWKPPNDPNGNITHY 651

  Fly   635 FVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGVLPYYSGPQPDDEDYYNKEQITYEDALPNL 699
            .|..::.....|....:|            |:....||..:..|.|:|:.....|.  |:..|:
Zfish   652 LVFCQQQPEASELYKFDY------------CQKGMKLPTRAPTQVDNEEEQKWNQT--EEQGPD- 701

  Fly   700 IYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENY----- 759
               ||.....:.|.:          :||:.|.|....|                  :|||
Zfish   702 ---SRCCACPKTEKQ----------LKKEAEETEYRKT------------------FENYLHNEV 735

  Fly   760 -RLNSEKKQRDLQDL----DQHKYTIRHALP----------KCQNSHASVVQQVEEKCVAEEPLS 809
             .|...:::|.|..:    ....:|...:||          :.:.:..|::.|.:|..|
Zfish   736 FELRPSRQRRSLVGIANRTSSRLFTTPSSLPNGSATRSPEEEAEANKISLIVQAKESTV------ 794

  Fly   810 GYELPGTQHFYCLSQLEPETHYRITIRACVEGV-VNGCSTPAEAVIKT 856
               :...:||         |.|:|.|.||..|. ...||..|....:|
Zfish   795 ---ISNLRHF---------TSYQIEIHACNHGSDPTRCSMAAYVSART 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	46/118 (39%)
		Furin-like	209..332	CDD:279142	37/144 (26%)
		Recep_L_domain	347..461	CDD:279382	46/116 (40%)
		FN3	491..578	CDD:214495	36/101 (36%)
insra	XP_005171317.1	Recep_L_domain	53..165	CDD:279382	46/118 (39%)
		Furin-like	179..337	CDD:279142	42/174 (24%)
		FU	234..281	CDD:238021	14/46 (30%)
		Recep_L_domain	356..470	CDD:279382	46/116 (40%)
		FN3	618..>660	CDD:238020	19/41 (46%)
		FN3	851..930	CDD:238020
		PTKc_InsR	996..1283	CDD:133192
		Pkinase_Tyr	1003..1270	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8342
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820