Protein Alignment Sdr and EPHB2

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_001296122.1
• Gene: EPHB2 / 2048
• HGNCID: 3393
• Length: 1055
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 65/274 - (23%)
• Similarity: 99/274 - (36%)
• Gaps: 62/274 - (22%)

  Fly   494 VEDLNSTAVRIILDY---MDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGH--DNWLMDVVPN 553
            :..:|.|:  ::|::   .|..|.|.|: |:...|...       .||..|..  ||  :...|.
Human   332 ISSVNETS--LMLEWTPPRDSGGREDLV-YNIICKSCG-------SGRGACTRCGDN--VQYAPR 384

  Fly   554 Q----SRRHVISGLKPYTQYAYFVKTLT----RTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGS 610
            |    ..|..||.|..:|||.:.::.:.    ::.:..|..:.:    ..|....||.|..::..
Human   385 QLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVN----ITTNQAAPSAVSIMHQV 445

  Fly   611 SEISSQILLHWWPPRRPNGVIKNYFV-----TAEKYNATKEAKDKNYVNVELENAKDI---DCEC 667
            |.....|.|.|..|.:|||||.:|.:     ...:||||......|.|.|:...|..|   ....
Human   446 SRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRA 510

  Fly   668 AGVLPY--YSGP---QPDDEDYYNKEQITYEDALPNLI-----------------YVSRNHDYRR 710
            ..|..|  |||.   |...|..|   |.:.::.||.:|                 .|.....:.|
Human   511 RTVAGYGRYSGKMYFQTMTEAEY---QTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFER 572

  Fly   711 KEFEKVINYEHLLS 724
            .:.|.....:|..|
Human   573 ADSEYTDKLQHYTS 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032
		Furin-like	210..332	CDD:395614
		Recep_L_domain	347..461	CDD:460032
		FN3	491..578	CDD:214495	23/96 (24%)
EPHB2	NP_001296122.1	EphR_LBD_B2	19..196	CDD:198445
		fn3	326..421	CDD:394996	23/100 (23%)
		fn3	437..520	CDD:394996	24/82 (29%)
		EphA2_TM	544..617	CDD:464211	6/43 (14%)
		PTKc_EphR_B	616..884	CDD:173638
		SAM_EPH-B2	910..980	CDD:188951
		PDZ-binding (in isoform 2). /evidence=ECO:0000255	984..986
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	990..1055