DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sdr and EPHA2

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:XP_054190833.1 Gene:EPHA2 / 1969 HGNCID:3386 Length:978 Species:Homo sapiens


Alignment Length:599 Identity:110/599 - (18%)
Similarity:178/599 - (29%) Gaps:214/599 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 KDCP-IACGL-------NGCDS------AGKCCDHNCVTGCYSQNCSLCANYQGRMGC------- 271
            |.|| :..||       .|.|:      ||.|.||..|..         ...:.||.|       
Human   201 KKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPP---------GGEEPRMHCAVDGEWL 256

  Fly   272 --VNQCV--ASYELNKRRCIGHRECR------ELGRIPLIRGYQCVKKCPGNQKEILVAKGIIHC 326
              :.||:  |.||..:..|   :.|.      |....|.:       :||  :..:...:|...|
Human   257 VPIGQCLCQAGYEKVEDAC---QACSPGFFKFEASESPCL-------ECP--EHTLPSPEGATSC 309

  Fly   327 QVECNGDFHVKSAADLEVLQDCVTINGSLTIELTNIKEKIVDALENALASVKEITGYLKVIHSAQ 391
            :.| .|.|....                             |..............||..:....
Human   310 ECE-EGFFRAPQ-----------------------------DPASMPCTRPPSAPHYLTAVGMGA 344

  Fly   392 LMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPNHLVIIQRGTLFFHLNPRLCYEKIHQ 456
            .:.|.:....|:...:.:|      |.|.   .|..||.:                    .:...
Human   345 KVELRWTPPQDSGGREDIV------YSVT---CEQCWPES--------------------GECGP 380

  Fly   457 LQGSLKSGE--------NISVADVSPNSN----------GERVICGDAVRSLNPKVEDLNSTAVR 503
            .:.|::..|        :::|:|:.|:.|          ...::...:.|:.:..:.......||
Human   381 CEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVR 445

  Fly   504 IILDYMDWEGMETL-IGYSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQSRRHVISGLKPYT 567
            :       ||..|. :..|:.........|..|:..:....|:...:|...:.....:..|.|.|
Human   446 L-------EGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDT 503

  Fly   568 QYAYFVKTLTRTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIK 632
            .|...|:.||:...    .|.||:..||||....|..|.:.|...:...:||          |:.
Human   504 TYLVQVQALTQEGQ----GAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLL----------VLA 554

  Fly   633 --NYFVTAEKYNATKEAKDKNYVNVELENAKDIDCECAGVLPYYSGPQPDDEDYYNKEQI----- 690
              .:|:...:.|               :.|:.               .|:|..:...||:     
Human   555 GVGFFIHRRRKN---------------QRARQ---------------SPEDVYFSKSEQLKPLKT 589

  Fly   691 -----TYEDALPN---LIYVSRNHD---YRRK-----EFEKVINYEHLL--SIKKDEEPTRPPTT 737
                 ||||  ||   |.:.:..|.   .|:|     ||.:|  |:.:|  |..|.|.|....|.
Human   590 YVDPHTYED--PNQAVLKFTTEIHPSCVTRQKVIGAGEFGEV--YKGMLKTSSGKKEVPVAIKTL 650

  Fly   738 TPAPTNATLAKERL 751
            ....|.    |:|:
Human   651 KAGYTE----KQRV 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032
Furin-like 210..332 CDD:395614 30/134 (22%)
Recep_L_domain 347..461 CDD:460032 11/113 (10%)
FN3 491..578 CDD:214495 16/87 (18%)
EPHA2XP_054190833.1 EphR_LBD_A2 30..203 CDD:198448 1/1 (100%)
fn3 332..426 CDD:394996 16/122 (13%)
fn3 440..521 CDD:394996 18/91 (20%)
EphA2_TM <558..612 CDD:464211 14/85 (16%)
PTKc_EphR_A2 609..877 CDD:133194 16/58 (28%)
SAM_EPH-A2 904..973 CDD:188942
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.