DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sdr and EGFR

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_005219.2 Gene:EGFR / 1956 HGNCID:3236 Length:1210 Species:Homo sapiens


Alignment Length:526 Identity:119/526 - (22%)
Similarity:193/526 - (36%) Gaps:145/526 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PISIAVPLILLFLGASSPVLASSDDQTAC----------GSLEINKIADLRKLQNCTHVVGHVRL 68
            |...|...:|..|.|..|...:.:::..|          |:.|.:.::..|...||..|:|::.:
Human     3 PSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEI 67

  Fly    69 AYVDLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSI----FPRLRIIRGQELLFDQYSL 129
            .|     |..||.| |....:.|::.|:       ||:|.::    ...|:||||.....:.|:|
Human    68 TY-----VQRNYDL-SFLKTIQEVAGYV-------LIALNTVERIPLENLQIIRGNMYYENSYAL 119

  Fly   130 VVYEN-----RNLRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQ 189
            .|..|     ..|:||.:..|..|..|.:|..:||.||.||::.|..::.:....:.|:......
Human   120 AVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHL 184

  Fly   190 SQCPLCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCD------SAGKCCDH 248
            ..|..|.....      |.|  ||.......:      |...|.|. ..|.      |...||.:
Human   185 GSCQKCDPSCP------NGS--CWGAGEENCQ------KLTKIICA-QQCSGRCRGKSPSDCCHN 234

  Fly   249 NCVTGC---YSQNCSLCANYQGRMGCVNQC-------VASYELNKRRCIGHRECRELGRIPLIRG 303
            .|..||   ...:|.:|..::....|.:.|       ..:|::         :....|:...  |
Human   235 QCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQM---------DVNPEGKYSF--G 288

  Fly   304 YQCVKKCPGNQ------------------------KEILVAKGIIHCQVECNG-------DFHVK 337
            ..||||||.|.                        ::....:|  .|:..|||       |....
Human   289 ATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEG--PCRKVCNGIGIGEFKDSLSI 351

  Fly   338 SAADLEVLQDCVTINGSLTI--------ELTNIKEKIVDALE-NALASVKEITGYLKV------- 386
            :|.:::..::|.:|:|.|.|        ..|:...  :|..| :.|.:||||||:|.:       
Human   352 NATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPP--LDPQELDILKTVKEITGFLLIQAWPENR 414

  Fly   387 --IHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVN----NYHLEHIWPPNHLVIIQRGTLFFHL 445
              :|:        .:||:.|||......:::|.||:    :..|      ..|..|..|.:....
Human   415 TDLHA--------FENLEIIRGRTKQHGQFSLAVVSLNITSLGL------RSLKEISDGDVIISG 465

  Fly   446 NPRLCY 451
            |..|||
Human   466 NKNLCY 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032 38/123 (31%)
Furin-like 210..332 CDD:395614 29/161 (18%)
Recep_L_domain 347..461 CDD:460032 33/127 (26%)
FN3 491..578 CDD:214495
EGFRNP_005219.2 Recep_L_domain 57..168 CDD:460032 38/123 (31%)
Approximate 75..300 61/258 (24%)
Furin-like 185..335 CDD:395614 32/177 (18%)
Recep_L_domain 361..481 CDD:460032 33/127 (26%)
Approximate 390..600 26/96 (27%)
GF_recep_IV 505..637 CDD:464344
TM_ErbB1 634..677 CDD:213054
Important for dimerization, phosphorylation and activation 688..704
PTKc_EGFR 704..1016 CDD:270683
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1137
Blue background indicates that the domain is not in the aligned region.

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