Protein Alignment Sdr and let-23

DIOPT Version :10

• Sequence 1: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_001300607.1
• Gene: let-23 / 174462
• WormBaseID: WBGene00002299
• Length: 1335
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 126/524 - (24%)
• Similarity: 219/524 - (41%)
• Gaps: 126/524 - (24%)

  Fly    20 PLILLFL--------GASSPVLASSD------------------DQTACGSLEI--------NKI 50
            |.:.|||        .|:||......                  |.:.|.....        |.:
 Worm     4 PFLFLFLIILIDTTIDAASPTSTQGSVTVRRRQRKIVVREWNLTDPSVCSGTTNGISRYGTGNIL 68

  Fly    51 ADLRKL-QNCTHVVGHVRLAYVDLTDV-----SGNYSLD-----------SLASNVTEISDYLMV 98
            .||..: :.|..|.|::.:.:::..::     |.|.::|           :...|:.||...|::
 Worm    69 EDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLII 133

  Fly    99 YRCTGLISLQSI-FPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQSGFIRVESNPLLC 162
            ||.    ::|.| |||||:|.|.|:..|. :|.:::|..:.|:.:.||..|::|.:.::.||.:|
 Worm   134 YRA----NIQKISFPRLRVIYGDEVFHDN-ALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMC 193

  Fly   163 FV-ETVDWIYLMGN-------ATRQH-FSLKHNRPQSQCPLCGSLSADFEFIRNSSERCWNVNTT 218
            :: :.:||..|:.:       .|..| ...::.:..::|.            .:.:::||.....
 Worm   194 YIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCH------------ESCNDKCWGSGDN 246

  Fly   219 QLRPQPPRLKDCPIACG---LNGCDSAGKCCDHNCVTGCYS---QNCSLCANYQGRMGCVNQCVA 277
            ..  |......||.:|.   .:...|:.:|||..|:.||..   :||..|:.|:....|:..|.:
 Worm   247 DC--QRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPS 309

  Fly   278 SYELNKRRCIGHRECREL----GRIPLIRGYQCVKKCPGNQKEILVAKGIIHCQVECNGDFHVKS 338
                  |:...|:..|.:    ||..  .|..|||:||   .|:|:...:  |...|:...|..:
 Worm   310 ------RKIFNHKTGRLVFNPDGRYQ--NGNHCVKECP---PELLIENDV--CVRHCSDGHHYDA 361

  Fly   339 AADLEVLQDC--------VTINGSLTIE-LTNIK--EKIVDAL--ENA--------LASVKEITG 382
            ..|:...:.|        .|::|.||.| |.|::  |:|...|  |:|        |.:||.::.
 Worm   362 TKDVRECEKCRSSSCPKICTVDGHLTNETLKNLEGCEQIDGHLIIEHAFTYEQLKVLETVKIVSE 426

  Fly   383 YLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPNHLVIIQRGTLFFHLNP 447
            |:.::.. ....|.||:||..|.|.||...::||.:.....||.: ..|.|.:|:.|.:....|.
 Worm   427 YITIVQQ-NFYDLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEEL-SLNSLKLIKTGAVLIMKNH 489

  Fly   448 RLCY 451
            ||||
 Worm   490 RLCY 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	35/132 (27%)
		Furin-like	210..332	CDD:395614	34/131 (26%)
		Recep_L_domain	347..461	CDD:460032	39/126 (31%)
		FN3	491..578	CDD:214495
let-23	NP_001300607.1	Recep_L_domain	77..205	CDD:460032	35/132 (27%)
		Furin-like	229..378	CDD:395614	38/175 (22%)
		Recep_L_domain	396..503	CDD:460032	31/100 (31%)
		GF_recep_IV	531..652	CDD:464344
		FU	702..752	CDD:214589
		FU	759..806	CDD:214589
		PK_Tyr_Ser-Thr	898..1153	CDD:462242