DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sdr and Insr

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_001316985.1 Gene:Insr / 16337 MGIID:96575 Length:1384 Species:Mus musculus


Alignment Length:946 Identity:263/946 - (27%)
Similarity:411/946 - (43%) Gaps:217/946 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 AVPLIL----LFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYV------ 71
            ||||::    |.:|.:..:....    .|..::| |.:..|.:|:||:.:.||:::..:      
Mouse    11 AVPLLVAVAALLVGTAGHLYPGE----VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE 71

  Fly    72 DLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRN 136
            |..|:|        ...:..|:|||:::|..||.||:.:||.|.:|||..|.|: |:||::|..:
Mouse    72 DFRDLS--------FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN-YALVIFEMVH 127

  Fly   137 LRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQ-----CP--- 193
            |:||||..|:.|..|.:|:|.|..||::.|:||..::.:....:..|  |:..::     ||   
Mouse   128 LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVL--NKDDNEECGDVCPGTA 190

  Fly   194 ----LCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGC 254
                .|.:...:.:|:    ||||..:..|        |.||..|..:||.:.|.||...|:..|
Mouse   191 KGKTNCPATVINGQFV----ERCWTHSHCQ--------KVCPTICKSHGCTAEGLCCHKECLGNC 243

  Fly   255 YSQN----CSLCANYQGRMGCVNQCVAS-YELNKRRCIGHRECREL------GRIP-----LIRG 303
            ...:    |..|.|:.....||..|... |.....||:....|::|      .|.|     :|..
Mouse   244 SEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHN 308

  Fly   304 YQCVKKCPG----NQKEILVAKGIIHCQVEC---NGDFHVKSAADLEVLQDCVTINGSLTIELTN 361
            .:|:.:||.    |...::....:..|...|   .|:..:.|....:.|:.|..|||||.|   |
Mouse   309 NKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLII---N 370

  Fly   362 IK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHL 424
            |:  ..:...||..|..::||:|:||:..|..|:||:|.:.|..|||:.|....|:.|.::|.:|
Mouse   371 IRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNL 435

  Fly   425 EHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVR 488
            ..:|. ..|.:.|.:|.||||.||:||..:||:::....:.......|::..:||::..|.:   
Mouse   436 RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN--- 497

  Fly   489 SLNPKVEDLNSTAVRIILD--YMDWE-----GMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNW 546
                  |.|..:.:|...|  .:.||     ....|:|:...|||||.||||.:||:..||.::|
Mouse   498 ------ELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSW 556

  Fly   547 -LMDVVP--------NQSRRH---VISGLKPYTQYAYFVKTL-TRTEYHIQIDAYSKIGYFQTLP 598
             ::|:.|        :|:..|   ::.||||:||||.||||| |.::......|.|.|.|.||..
Mouse   557 TVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDA 621

  Fly   599 DRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYV---------- 653
            ..||..|.....|..||||:|.|.||..|||.|.:|.|..|:.....|..:.:|.          
Mouse   622 TNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRT 686

  Fly   654 --------NVELENAKDID------CECAGVLPYYSGPQPD-------DEDYYNKEQITYEDALP 697
                    :.:..|..:.|      |.|         |:.|       :|..:.|   |:||.|.
Mouse   687 WSPPFESDDSQKHNQSEYDDSASECCSC---------PKTDSQILKELEESSFRK---TFEDYLH 739

  Fly   698 NLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRLN 762
            |:::|.|.                 .|.....|.:||                            
Mouse   740 NVVFVPRK-----------------TSSGNGAEDSRP---------------------------- 759

  Fly   763 SEKKQRDLQDLDQHKYTIRHALPKCQNSHASVV--QQVE----EKCVAEEPLSGYELPGTQHFYC 821
             .:|:|.|:::.....|.. .||...|..:::|  .|.|    ||.|.:|.|   .:.|.:||  
Mouse   760 -SRKRRSLEEVGNVTATTL-TLPDFPNVSSTIVPTSQEEHRPFEKVVNKESL---VISGLRHF-- 817

  Fly   822 LSQLEPETHYRITIRAC-VEGVVNGCSTPAEAVIKT 856
                   |.|||.::|| .:.....||..|....:|
Mouse   818 -------TGYRIELQACNQDSPDERCSVAAYVSART 846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032 44/120 (37%)
Furin-like 210..332 CDD:395614 36/144 (25%)
Recep_L_domain 347..461 CDD:460032 45/116 (39%)
FN3 491..578 CDD:214495 39/106 (37%)
InsrNP_001316985.1 Recep_L_domain 52..164 CDD:460032 44/120 (37%)
Furin-like 179..337 CDD:395614 39/169 (23%)
Recep_L_domain 359..472 CDD:460032 45/115 (39%)
FN3 <584..>660 CDD:442628 37/75 (49%)
FN3 624..>667 CDD:238020 19/42 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 688..709 2/20 (10%)
Insulin-binding. /evidence=ECO:0000250 735..743 4/7 (57%)
FN3 869..946 CDD:238020
Insulin_TMD 942..989 CDD:465543
Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250 998..1001
PTKc_InsR 1018..1305 CDD:133192
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1361..1384
PIK3R1 binding. /evidence=ECO:0000250 1363..1366
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.