DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and Igf1r

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_006540704.1	Gene:	Igf1r / 16001	MGIID:	96433	Length:	1401	Species:	Mus musculus

Alignment Length:	924	Identity:	265/924 - (28%)
Similarity:	415/924 - (44%)	Gaps:	203/924 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLFLGASSPVLASSDDQTACG-SLEI-NKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDSL 85
            |:||.|:..:..:|.:  .|| .::| |....|::|:|||.:.|.:.:..:...:...:|....|
Mouse    16 LVFLSAALSLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKL 78

  Fly    86 ASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQS 150
                |.|::||:::|..||.||..:||.|.:|||.:|.:: |:||::|..||:::||..|..|..
Mouse    79 ----TVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN-YALVIFEMTNLKDIGLYNLRNITR 138

  Fly   151 GFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQC-----------PLCGSLSADFEF 204
            |.||:|.|..||::.|:||..::...:..:  :..|:|..:|           |:|...:.:.|:
Mouse   139 GAIRIEKNADLCYLSTIDWSLILDAVSNNY--IVGNKPPKECGDLCPGTLEEKPMCEKTTINNEY 201

  Fly   205 IRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCYSQN----CSLCANY 265
                :.|||..|..|        |.||..||...|....:||...|:..|::.:    |..|.:|
Mouse   202 ----NYRCWTTNRCQ--------KMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHY 254

  Fly   266 QGRMGCVNQC-VASYELNKRRCIGHRECRELGRIP----------LIRGYQCVKKCPG----NQK 315
            ..:..||..| ..:|.....||:....|   ..||          :|...:|:::||.    |..
Mouse   255 YYKGVCVPACPPGTYRFEGWRCVDRDFC---ANIPNAESSDSDGFVIHDDECMQECPSGFIRNST 316

  Fly   316 EILVAKGIIHCQVECN---GDFHVK-----SAADLEVLQDCVTINGSLTIELTNIK--EKIVDAL 370
            :.:..   |.|:..|.   ||...|     |....::||.|..:.|:|   |.||:  ..|...|
Mouse   317 QSMYC---IPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNL---LINIRRGNNIASEL 375

  Fly   371 ENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHLEHIWPPNHL-V 434
            ||.:..::.:|||:|:.||..|:||:||:||..|.|::.:|..|:.||::|.:|:.:|..||. :
Mouse   376 ENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNL 440

  Fly   435 IIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVIC-GDAVRSLNPKVEDLN 498
            .::.|.::|..||:||..:|::::....:....|..|::..:||||..| .|.:|        ..
Mouse   441 TVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLR--------FT 497

  Fly   499 STAV---RIIL--------DYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLM---D 549
            ||..   |||:        ||.|      ||.::.:|||||.:|||.|||:..||.::|.|   |
Mouse   498 STTTWKNRIIITWHRYRPPDYRD------LISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVD 556

  Fly   550 VVPNQSRRH--VISGLKPYTQYAYFVK--TLTRTEY-HIQIDAYSKIGYFQTLPDRPSPVLRIYG 609
            :.||:....  ::.||||:||||.:||  |||..|. ||: .|.|:|.|.:|....||..|.:..
Mouse   557 LPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIR-GAKSEILYIRTNASVPSIPLDVLS 620

  Fly   610 SSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYVN----VELENAKD--IDCE-- 666
            :|..|||:::.|.||..|||.:..|.|..::..........||.:    :.:....|  ||.|
Mouse   621 ASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKADKIPIRKYADGTIDVEEV 685

  Fly   667 --------CAGVL-PYYSGPQPDDEDYYNKEQITY----EDALPNLIYVSRNHDYRRKEFEKVIN 718
                    |.|.. |..:.|:.:.|....||:..|    |:.|.|.|:|.| .:.||::..:|.|
Mouse   686 TENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPR-PERRRRDVMQVAN 749

  Fly   719 YEHLLSIKKDEEPTRPPTTTPAPT-NATLAKERLAAINYENYRLNSEKKQRDLQDLDQHKYTIRH 782
                     ....:|...||.|.| |.|..:|  ....|..:....:.|:|.:
Mouse   750 ---------TTMSSRSRNTTVADTYNITDPEE--FETEYPFFESRVDNKERTV------------ 791

  Fly   783 ALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLEPETHYRITIRAC-VEGVVNGC 846
                                                   :|.|.|.|.|||.|.:| .|....||
Mouse   792 ---------------------------------------ISNLRPFTLYRIDIHSCNHEAEKLGC 817

  Fly   847 ST---------PAE 851
            |.         |||
Mouse   818 SASNFVFARTMPAE 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	42/114 (37%)
		Furin-like	209..332	CDD:279142	35/144 (24%)
		Recep_L_domain	347..461	CDD:279382	41/116 (35%)
		FN3	491..578	CDD:214495	40/104 (38%)
Igf1r	XP_006540704.1	Recep_L_domain	51..159	CDD:366426	42/112 (38%)
		Furin-like	175..332	CDD:366287	39/174 (22%)
		Recep_L_domain	353..466	CDD:366426	41/115 (36%)
		FN3	494..607	CDD:238020	49/127 (39%)
		FN3	612..>656	CDD:238020	15/43 (35%)
		FN3	837..926	CDD:238020
		PTKc_InsR_like	994..1302	CDD:173625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8331
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.770