DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sdr and Erbb4

DIOPT Version :10

Sequence 1:NP_650408.1 Gene:Sdr / 41809 FlyBaseID:FBgn0038279 Length:868 Species:Drosophila melanogaster
Sequence 2:XP_006495755.1 Gene:Erbb4 / 13869 MGIID:104771 Length:1308 Species:Mus musculus


Alignment Length:660 Identity:144/660 - (21%)
Similarity:235/660 - (35%) Gaps:232/660 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ILLFLGASSPVLASSDDQTACGSLEINKIADLRKL-----------QNCTHVVGHVRLAYVDLTD 75
            :|:..|...|    |..|:.|...| ||::.|..|           :||..|:|:     :::|.
Mouse    13 LLMAAGTVQP----SASQSVCAGTE-NKLSSLSDLEQQYRALRKYYENCEVVMGN-----LEITS 67

  Fly    76 VSGNYSLDSLASNVTEISDYLMV----YRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVY---- 132
            :..|..|..|.| :.|::.|::|    :|...|       ..||||||.:|..|:|:|.::    
Mouse    68 IEHNRDLSFLRS-IREVTGYVLVALNQFRYLPL-------ENLRIIRGTKLYEDRYALAIFLNYR 124

  Fly   133 --ENRNLRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQCPLC 195
              .|..|:||||..|..|.:|.:.|:.|..||:.:|:.|..::.|....:.:|......|.|..|
Mouse   125 KDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGRC 189

  Fly   196 GSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCP----IACGLNGCDS------AGKCCDHNC 250
            .         ::.:.|||.          |....|.    ..|. ..||.      ...||...|
Mouse   190 H---------KSCTGRCWG----------PTENHCQTLTRTVCA-EQCDGRCYGPYVSDCCHREC 234

  Fly   251 VTGC---YSQNCSLCANYQGRMGCVNQCVASYELNKRR----------------CIGHRECRELG 296
            ..||   ...:|..|.|:.....||.||..::..|...                |:  ::|    
Mouse   235 AGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCV--KKC---- 293

  Fly   297 RIP---LIRGYQCVKKCPGNQKEILVAKGIIHCQ-------VECNG-------DFHVKSAADLEV 344
              |   ::....||:.||.::.|: ...||..|:       ..|:|       ......:::::.
Mouse   294 --PHNFVVDSSSCVRACPSSKMEV-EENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDK 355

  Fly   345 LQDCVTINGSLTIELTNI---KEKIVDALE----NALASVKEITGYLKVIHSAQLMSLTFLQNLD 402
            ..:|..|||:|...:|.|   ....:||::    |...:|:||||:|.:                
Mouse   356 FINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNI---------------- 404

  Fly   403 AIRGDKLVENKYALYVVNNYHLEHIWPPN--------HLVIIQRGTLFFHLNPRLCYEK-IHQLQ 458
                                   ..||||        :||.|....|:..|:..:..:: |..||
Mouse   405 -----------------------QSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQ 446

  Fly   459 -GSLK--SGENISVADVSPNSN----------------GERVICGDAVRSLNPKVEDLNSTAVRI 504
             .|||  |..||.:.|   |||                .:|::..|     |.:.|  |.||..:
Mouse   447 FQSLKEISAGNIYITD---NSNLCYYHTINWTTLFSTINQRIVIRD-----NRRAE--NCTAEGM 501

  Fly   505 ILDYM-----DW-EGMETLIG-YSYHYKEAPVQNVTMYDGR------------------------ 538
            :.:::     .| .|.:..:. ..:...:..:::..:|||.                        
Mouse   502 VCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGL 566

  Fly   539 ---HGCGHDN 545
               ||.|.||
Mouse   567 LTCHGPGPDN 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SdrNP_650408.1 Recep_L_domain 58..173 CDD:460032 39/124 (31%)
Furin-like 210..332 CDD:395614 33/160 (21%)
Recep_L_domain 347..461 CDD:460032 28/130 (22%)
FN3 491..578 CDD:214495 15/89 (17%)
Erbb4XP_006495755.1 Recep_L_domain 55..167 CDD:460032 39/124 (31%)
Furin-like 186..332 CDD:395614 34/174 (20%)
Recep_L_domain 358..478 CDD:460032 38/161 (24%)
GF_recep_IV 502..634 CDD:464344 10/75 (13%)
TM_ErbB4 642..685 CDD:213053
PTKc_HER4 710..1012 CDD:173655
Blue background indicates that the domain is not in the aligned region.

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