DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdr and insr

DIOPT Version :9

Sequence 1:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_002934425.2	Gene:	insr / 100492718	XenbaseID:	XB-GENE-920733	Length:	1360	Species:	Xenopus tropicalis

Alignment Length:	952	Identity:	276/952 - (28%)
Similarity:	405/952 - (42%)	Gaps:	218/952 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GHLHPVPNPLPIP--ISIAVPLILLFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVV 63
            |..||..||....  .|||...|:..|     :|...:|...|.|::| |.|:....|::||.:.
Frog     8 GEGHPNNNPKSKVGWKSIAGIFIIFML-----ILCDQNDGKICPSMDIRNNISQFSMLEDCTVIE 67

  Fly    64 GHVRLAYVDLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYS 128
            ||:::..: .|....|:. ......:|.|:|||:::|..||.||:.:||.|.:|||..|.|: |:
Frog    68 GHLQILLM-FTSKPENFR-GLRFPKLTMITDYLLLFRVYGLESLKDLFPNLTVIRGTHLFFN-YA 129

  Fly   129 LVVYENRNLRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQ-- 191
            ||::|..:|:|:||..|:.|..|.:|:|.|..||::.|:||..::.:....:..|  ||...:
Frog   130 LVIFEMVHLKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIEL--NRDNKEEC 192

  Fly   192 ---CP-------LCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCC 246
               ||       .|..:..:..||    ||||..:..|        ..||..|..:||...|:||
Frog   193 GDVCPGAGKGKSKCKQIVVNGAFI----ERCWTQDHCQ--------TVCPSECKGSGCLPDGQCC 245

  Fly   247 DHNCVTGCYSQN----CSLCANYQGRMGCVNQC-VASYELNKRRCIGHRECREL-GRIP------ 299
            ...|:..|...|    |:.|.:||.:..|::.| ..||.....|||....|:|: .|.|
Frog   246 HSECLGSCRKPNDPTECTACRHYQYQGVCISACPEGSYRFQGWRCIDFNTCQEMHNRCPNKENSC 310

  Fly   300 ---LIRGYQCVKKCPGNQKEILVAKGIIHCQVECNGDF-----------HVKSAADLEVLQDCVT 350
               :|...:|:..||..    .:|.........|.|..           .:.|....:.|:.|..
Frog   311 PPYVIHKGECMPDCPSG----YIANSTTRTCTPCAGPCPKVCTIYQSVKTIDSVTSAQELRGCTV 371

  Fly   351 INGSLTIELTNIK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENK 413
            :||||.|   ||:  ..|...||..|..::||:||||:..|..|:||:|.:.|..|||:.|....
Frog   372 VNGSLII---NIRGGNNIATELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGEVLEAGN 433

  Fly   414 YALYVVNNYHLEHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSN 477
            |:.|.::|..|..:|. ..|.:.|..|.||||.|||||..:|||::....:.......|:|..:|
Frog   434 YSFYALDNPSLRQLWDWHKHNLTIIHGKLFFHHNPRLCLAEIHQMEEVTGTKGRQDKNDISTKTN 498

  Fly   478 GERVICGDAVRSLNPKVEDLNSTAVRIIL--------DYMDWEGMETLIGYSYHYKEAPVQNVTM 534
            |::..|.|.:.:.|    .:.::...::|        ||.|      |:|:..||||||.||||.
Frog   499 GDQASCEDNLLNFN----FIRTSHDMVLLKWDPYWPPDYRD------LLGFMVHYKEAPYQNVTE 553

  Fly   535 YDGRHGCGHDNWL---MDVVPNQSRRHVIS------GLKPYTQYAYFVKTLT------RTEYHIQ 584
            :||:..||.::|.   ||.....:....:|      .|||:||||.|||||.      ||
Frog   554 FDGQDACGSNSWTVVDMDAPERSADGKTLSPGCLLRNLKPWTQYAVFVKTLVSGSDEGRT----- 613

  Fly   585 IDAYSKIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKD 649
            ..|.|||.|.:|....||..|..:..|..:|||:|.|.||..|||.:.:|.|..::.....|..:
Frog   614 YGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPPSEPNGNVTHYLVYWQEQPEDSELYE 678

  Fly   650 KNYVNVELE----------------NAKDID------CECAGVLPYYSGPQPD-------DEDYY 685
            .:|.|..|:                |....|      |.|         |:.|       ||..:
Frog   679 LDYCNKGLKLPSRTWTPPSDIEENGNINQTDQPSSKCCPC---------PKTDFQIQKEQDESAF 734

  Fly   686 NKEQITYEDALPNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRP-PTTTPAPTNATLAKE 749
            .|   |:|:.|.|.:::.|....||:.| .|.|            .|.| |.|.|:..||:
Frog   735 RK---TFENYLHNEVFIPRPVRKRRELF-GVAN------------GTLPDPVTAPSLFNAS---- 779

  Fly   750 RLAAINYENYRLNSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELP 814
                    :.|...|.:                  ||..:          :|...:|.|.   :.
Frog   780 --------STRAPDETE------------------PKIYS----------QKVWFKESLM---VT 805

  Fly   815 GTQHFYCLSQLEPETHYRITIRACVEGVVNGCSTPAEAVIKT 856
            |.:||         |.|||.|.||...:..|||..|....:|
Frog   806 GLKHF---------TGYRIEIHACNHELSMGCSVAAYVSART 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	43/114 (38%)
		Furin-like	209..332	CDD:279142	37/137 (27%)
		Recep_L_domain	347..461	CDD:279382	48/116 (41%)
		FN3	491..578	CDD:214495	37/109 (34%)
insr	XP_002934425.2	Recep_L_domain	62..171	CDD:366426	42/111 (38%)
		Furin-like	189..349	CDD:366287	43/175 (25%)
		Recep_L_domain	368..481	CDD:366426	48/115 (42%)
		FN3	510..625	CDD:238020	44/129 (34%)
		FN3	630..>673	CDD:238020	16/42 (38%)
		FN3	851..939	CDD:238020
		Insulin_TMD	936..979	CDD:375394
		PTKc_InsR	1003..1290	CDD:133192
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6897
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010