DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3817 and RRP15

DIOPT Version :9

Sequence 1:	NP_650405.2	Gene:	CG3817 / 41805	FlyBaseID:	FBgn0038275	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	XP_011507899.1	Gene:	RRP15 / 51018	HGNCID:	24255	Length:	368	Species:	Homo sapiens

Alignment Length:	214	Identity:	63/214 - (29%)
Similarity:	104/214 - (48%)	Gaps:	45/214 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SDSSPEESDSEG--------SQNSASEAEG-NAGWADSIQKVLKTTKPKTQKKTVLARAKKSQAA 72
            ||....|:||||        ::|....:.| |.||||::.|||....|:: |.|:|.:.||
Human    58 SDDDAIEADSEGDAEPCDKENENDGESSVGTNMGWADAMAKVLNKKTPES-KPTILVKNKK---- 117

  Fly    73 VRFQKDAANKKPGFDFEIEKADVKEEDEGDNHEDEKPQASALDATLTKQQRKNVPLQLRVKPS-F 136
                             :||            |.||.:...|:....:.:|....:..||||. .
Human   118 -----------------LEK------------EKEKLKQERLEKIKQRDKRLEWEMMCRVKPDVV 153

  Fly   137 RDMERERTLRKVATRGVVQFFNAVRIQQKDLQQQLEEAGPLDSRQDAVLNNINKRKFLDVLMSGK 201
            :|.|.||.|:::|||||||.||||:..||::.::::|||....::..:::.::|:.|:.|| .|.
Human   154 QDKETERNLQRIATRGVVQLFNAVQKHQKNVDEKVKEAGSSMRKRAKLISTVSKKDFISVL-RGM 217

  Fly   202 RAKSTPVDNAVKKEEQETD 220
            ...:....::.||.:.:.|
Human   218 DGSTNETASSRKKPKAKQD 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3817	NP_650405.2	Rrp15p	<105..198	CDD:285173	33/93 (35%)
RRP15	XP_011507899.1	Rrp15p	102..215	CDD:285173	42/147 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154211
Domainoid	1	1.000	70	1.000	Domainoid score	I9598
eggNOG	1	0.900	-	-		E1_KOG2974
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4914
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50095
OrthoDB	1	1.010	-	-		D1522334at2759
OrthoFinder	1	1.000	-	-		FOG0004819
OrthoInspector	1	1.000	-	-		oto90285
orthoMCL	1	0.900	-	-		OOG6_103633
Panther	1	1.100	-	-	LDO	PTHR13245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2773
SonicParanoid	1	1.000	-	-		X5159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800