DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-2 and NUP93

DIOPT Version :9

Sequence 1:	NP_650404.1	Gene:	Nup93-2 / 41804	FlyBaseID:	FBgn0038274	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_055484.3	Gene:	NUP93 / 9688	HGNCID:	28958	Length:	819	Species:	Homo sapiens

Alignment Length:	829	Identity:	302/829 - (36%)
Similarity:	463/829 - (55%)	Gaps:	56/829 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLQRAQNLNNDAKAECELPAVERTLQQVLRATTELHSR-VTQTG--CKEIQAHILLGSKGVDLPK 67
            |||:|:.|..:.:...|||.|||.||::.:|...|.|| :|:|.  ..:::|.:||||:|:|:..
Human     9 LLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLGSRGLDISH 73

  Fly    68 LNQKLEALSARKTFEPLDVKADTDVRTFLKNERENAILSVIEDTKKNISDSANKQRWASMNKVWN 132
            ::|:||:|||..|||||:...|||::.|||||::||:||.||:::|.....|.:....||...|.
Human    74 ISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWE 138

  Fly   133 EEKTRLLDALIAPSQNFIDLQRLPEPTIVNPLCQP-RSCLDPLELVYAQELRHYNELLLKSSHRP 196
            :.|.|:|..|:|..::.:|..:..||:.::.:..| ||.||.:|:.||:::..|||.::....:|
Human   139 QVKQRILHTLLASGEDALDFTQESEPSYISDVGPPGRSSLDNIEMAYARQIYIYNEKIVNGHLQP 203

  Fly   197 NLVQKFAHLSQSFGDCRLTDMWTLLACVTQISEPLRSDPIKSR---QQRPEFVTYAKSYLERRYR 258
            |||...|.::: ..|..::||||::..:|.:.....:|.:|:|   :.|.|||..|.:|||:.|:
Human   204 NLVDLCASVAE-LDDKSISDMWTMVKQMTDVLLTPATDALKNRSSVEVRMEFVRQALAYLEQSYK 267

  Fly   259 VFMC---------SQVGGSYANNSYQLVVAYVNHRFRAQQTIGLVD-TVREIPLWPLVYYGLRCG 313
            .:..         :|:||  ...:||||.:::|.:..|... ||.| .|...|:|.|:||.:|||
Human   268 NYTLVTVFGNLHQAQLGG--VPGTYQLVRSFLNIKLPAPLP-GLQDGEVEGHPVWALIYYCMRCG 329

  Fly   314 AVKVAVEFLREAGSSHDEFAQLVADRNAGETNSK-------IENQLRLQYANKIRNSTDAYKKAV 371
            .:..|.:.:..|.....||.....:    ..|||       .||:|||.|...:||:||.||:||
Human   330 DLLAASQVVNRAQHQLGEFKTWFQE----YMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAV 390

  Fly   372 YCILLGCDVNEVHGEVAKTIDDFLWMRLAMI--------QPGDADNYGKLQSMILEQYGEKYFNA 428
            |||:..|||.:...|||...:|:||::|..:        .|.|.....:.|..:||.|||.:|..
Human   391 YCIIGRCDVTDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTV 455

  Fly   429 RQQPYLYFETLALTGQFEAAIEFLARQDENRAHAVHMAIALFELGLLGSARSVSQPLLSIDIKDP 493
            .|||:|||:.|.||.|||||:.||.|.:..|.||||:|:.||||.||..:...|..|||.:..||
Human   456 NQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDP 520

  Fly   494 QPLRRLNLTRLIRQYVQRFERTDTSEALHYYYTLRCLKDSKGRNMFMACVCDLVVDSGVFDTTIF 558
            ..|||||..||:..|.::||.||..|||.|:|.||..|||:|.|||:.||.:||::|     ..|
Human   521 PCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMFLRCVSELVIES-----REF 580

  Fly   559 DLIFGKRQSSDQNDVNSGLFRQFECPEFDTRTMAAQVGDELAALGNFEMSARLYEMAGKYNLAVK 623
            |:|.||.::....  ..|:..:|..   ||:.:..:|.......|.||.:|:||::|...:..::
Human   581 DMILGKLENDGSR--KPGVIDKFTS---DTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLE 640

  Fly   624 HICILMAQVVHLPTLGGSLRERLGQDAQRFNQLLASDSIDVEPKMKSSFVLLQDLLIFFNFYHDG 688
            .:..|::.||...:...|.:|||...|....:...:..|.....:.|:|.||.||:.||:.||.|
Human   641 LMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSG 705

  Fly   689 KFNAALDLLRQTQLVPNTLDDVDVVLGNVKQLSGEVIKVLPDVIVAAMEIAQKQYKQLKAGSGSS 753
            ..:.|.|::.:.:|||...:.|:..:...:..|.|:...|.:|::|.|.|...|:|:||..|.||
Human   706 HIDRAFDIIERLKLVPLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSS 770

  Fly   754 LEQTQM------QQLRQRAKALSNMAATMPYRLPNDTNKRLIELELDMH 796
            ..:.|.      .|||.:|:.|...|..:|||...|||.||:::|:.|:
Human   771 SSRPQRVIEDRDSQLRSQARTLITFAGMIPYRTSGDTNARLVQMEVLMN 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-2	NP_650404.1	DUF2461	178..>238	CDD:295279	17/59 (29%)
Nup93-2	NP_650404.1	Nic96	213..781	CDD:282017	214/601 (36%)
NUP93	NP_055484.3	Nic96	220..802	CDD:397976	212/598 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154988
Domainoid	1	1.000	327	1.000	Domainoid score	I1173
eggNOG	1	0.900	-	-		E1_KOG2168
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40971
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1494
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59183
OrthoDB	1	1.010	-	-		D187731at2759
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm40363
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	LDO	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	1	1.000	-	-		X3522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800