DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-2 and NIC96

DIOPT Version :9

Sequence 1:	NP_650404.1	Gene:	Nup93-2 / 41804	FlyBaseID:	FBgn0038274	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_116657.1	Gene:	NIC96 / 850552	SGDID:	S000001898	Length:	839	Species:	Saccharomyces cerevisiae

Alignment Length:	909	Identity:	181/909 - (19%)
Similarity:	360/909 - (39%)	Gaps:	207/909 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNTLLQRAQNLNNDAKAECELPAVERTLQQVLRATTELHSRVTQTGCKEIQAHILLGSKGVDLPK 67
            ||.||:.:.||   ..|..||.:::.::.::.|...:|.|: .:......:||.||.:.|:....
Yeast    22 LNELLESSDNL---PSASSELGSIQVSINELRRRVFQLRSK-NKASKDYTKAHYLLANSGLSFED 82

  Fly    68 LNQKLEALSARKTFEPLDVK--ADTDVRTFLKNERENAILSVIED----TKKNISDSANKQRWAS 126
            ::..::.|...:..||...|  ...::..:::.::|..||..||.    ..|:..:..|.    :
Yeast    83 VDAFIKDLQTNQFLEPNPPKIIESEELEFYIRTKKEENILMSIEQLLNGATKDFDNFINH----N 143

  Fly   127 MNKVWNEEKTRLLD--ALIAPSQNFIDLQRLPEPTIVNPLCQPRSCLDPL---------ELVYAQ 180
            :|..|.:.|..::.  .::...:..:|.::            ..|.|||.         .::.:.
Yeast   144 LNLDWAQHKNEVMKNFGILIQDKKTVDHKK------------SISSLDPKLPSWGNKGNNILNSN 196

  Fly   181 ELR-HYNE---LLLKSSHRPNLVQKFAHLSQSFG-------------------DCRLTDMWTLLA 222
            |.| :.||   |..|..:...:|.:|.:..|:.|                   :.:|.:.|.:|
Yeast   197 ESRLNVNENNILREKFENYARIVFQFNNSRQANGNFDIANEFISILSSANGTRNAQLLESWKIL- 260

  Fly   223 CVTQISEPLRSDPIKSRQQRPEFVTYAKSYLERRYRVFMCSQVGGSYANNSYQ------------ 275
                  |.::|..|       ..|...|.|||:::.         .|.:|.|:
Yeast   261 ------ESMKSKDI-------NIVEVGKQYLEQQFL---------QYTDNLYKKNMNEGLATNVN 303

  Fly   276 LVVAYVNHRFRAQQ---TIGLVDTVREIPLWPLVYYGLRCGAVKVAVEFLREAGSSHDEFAQLVA 337
            .:.::::.:.:...   .|..:..:..:|:|.|::|.||.|.:|.|::.|.|..::..:..|...
Yeast   304 KIKSFIDTKLKKADKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANIKKVEQSFL 368

  Fly   338 DRNAGETNSK-------IENQLRLQYANKIRNSTDA--YKKAVYCILLGCDVNEVH-GEVAKTID 392
            .......:||       ...:|..:|...|::|.|.  |:.|||.::..||::..: ..|..:|:
Yeast   369 TYFKAYASSKDHGLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDLSRKNIPAVTLSIE 433

  Fly   393 DFLWMRLAMIQPGDADN---YGK-----LQSMILEQYGEKYFNARQQPYLYFETLALTGQFEAAI 449
            |:|||.|.:|:..||:|   |.:     .|::|: .||...|:     ..|.:||.|:|.:..||
Yeast   434 DWLWMHLMLIKEKDAENDPVYERYSLEDFQNIII-SYGPSRFS-----NYYLQTLLLSGLYGLAI 492

  Fly   450 EFLARQDENRAHAVHMAIALFELGL--LGSARSVSQPLLSIDIKDPQPLRRLNLTRLIRQYVQRF 512
            ::.....|  ..|||:||.|..|.|  :.|:..:::          :|.|.:....::..|.:.|
Yeast   493 DYTYTFSE--MDAVHLAIGLASLKLFKIDSSTRLTK----------KPKRDIRFANILANYTKSF 545

  Fly   513 ERTDTSEALHYYYTLRCLKDSKGRNMFMACVCDLVVDSGVFDTTIFDLIFGK------------- 564
            ..:|...|:.|...:...:......:     |...:...|.:|..|.::.||
Yeast   546 RYSDPRVAVEYLVLITLNEGPTDVEL-----CHEALRELVLETKEFTVLLGKIGRDGARIPGVIE 605

  Fly   565 -RQS----SDQNDVNSGLFRQFECPEFDTRTMAAQVGDELAALGNFEMSARLYEMAGKYNLAVKH 624
             ||.    .|:.:....:..|           ||:..||   .|....|..||::|.:|::.:..
Yeast   606 ERQPLLHVRDEKEFLHTITEQ-----------AARRADE---DGRIYDSILLYQLAEEYDIVITL 656

  Fly   625 ICILMAQVVHLPTLGGSLRERLGQD----------AQRFNQLL---ASDSIDVEPKMKSSFVLLQ 676
            :..|::..:....|...|   :|.|          |:|...:.   |..|..:..|.|...:||.
Yeast   657 VNSLLSDTLSASDLDQPL---VGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLL 718

  Fly   677 DLLIFFNFYHDGKFNAALDLLRQTQLVPNTLDDVDV--VLGNVKQLSGEVIKVLPDVIVAAME-- 737
            ::......|.:.::...|..:....|:|.: |::..  ...:...|...::|.:|::::..:.
Yeast   719 NISSIRELYFNKQWQETLSQMELLDLLPFS-DELSARKKAQDFSNLDDNIVKNIPNLLIITLSCI 782

  Fly   738 ------IAQKQYKQLKAGSGSSLEQTQMQQLRQRAKALSNMAATMPYRLPNDTNKRLIELELDM 795
                  :.:.:|:       ||.:..|:..|:..|:.....|..:.||:|.:|...||.:::.:
Yeast   783 SNMIHILNESKYQ-------SSTKGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-2	NP_650404.1	DUF2461	178..>238	CDD:295279	16/82 (20%)
Nup93-2	NP_650404.1	Nic96	213..781	CDD:282017	131/643 (20%)
NIC96	NP_116657.1	Nic96	252..825	CDD:397976	131/643 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345184
Domainoid	1	1.000	114	1.000	Domainoid score	I1326
eggNOG	1	0.900	-	-		E1_KOG2168
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40971
Inparanoid	1	1.050	136	1.000	Inparanoid score	I1207
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59183
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm46509
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	LDO	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	1	1.000	-	-		X3522
TreeFam	1	0.960	-	-
	15	14.790