DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-2 and Nup93

DIOPT Version :9

Sequence 1:	NP_650404.1	Gene:	Nup93-2 / 41804	FlyBaseID:	FBgn0038274	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_001344195.1	Gene:	Nup93 / 71805	MGIID:	1919055	Length:	819	Species:	Mus musculus

Alignment Length:	829	Identity:	301/829 - (36%)
Similarity:	461/829 - (55%)	Gaps:	56/829 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLQRAQNLNNDAKAECELPAVERTLQQVLRATTELHSR-VTQTG--CKEIQAHILLGSKGVDLPK 67
            |||:|:.|..:.:...|||.|||.||::.:|...|.|| :|:|.  ..:::|.:||||:|:|:..
Mouse     9 LLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLGSRGLDISH 73

  Fly    68 LNQKLEALSARKTFEPLDVKADTDVRTFLKNERENAILSVIEDTKKNISDSANKQRWASMNKVWN 132
            ::|:||:|||..|||||:...|||::.|||||::||:||.||:::|.....|.:....||...|.
Mouse    74 ISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWE 138

  Fly   133 EEKTRLLDALIAPSQNFIDLQRLPEPTIVNPLCQP-RSCLDPLELVYAQELRHYNELLLKSSHRP 196
            :.|.|:|..|:|..::.:|..:..||:.:..:..| ||.||.:|:.||:::..|||.::....:|
Mouse   139 QVKQRILHTLLASGEDALDFTQESEPSYIGDVNPPGRSSLDSIEMAYARQIYIYNEKIVSGHLQP 203

  Fly   197 NLVQKFAHLSQSFGDCRLTDMWTLLACVTQISEPLRSDPIKSR---QQRPEFVTYAKSYLERRYR 258
            |||...|.::: ..|..::|||.::..:|.:.....:|.:|||   :.|.:||..|..|||:.|:
Mouse   204 NLVDLCASVAE-LDDKSISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYK 267

  Fly   259 VFMC---------SQVGGSYANNSYQLVVAYVNHRFRAQQTIGLVD-TVREIPLWPLVYYGLRCG 313
            .:..         :|:||  ...:||||.:::|.:..|... ||.| .|...|:|.|:||.:|||
Mouse   268 NYTLVTVFGNLHQAQLGG--VPGTYQLVRSFLNIKLPAPSP-GLQDGEVEGHPVWALIYYCMRCG 329

  Fly   314 AVKVAVEFLREAGSSHDEFAQLVADRNAGETNSK-------IENQLRLQYANKIRNSTDAYKKAV 371
            .:..|.:.:..|.....||.....:    ..|||       .||:|||.|...:||:||.||:||
Mouse   330 DLLAASQVVSRAQHQLGEFKTWFQE----YMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAV 390

  Fly   372 YCILLGCDVNEVHGEVAKTIDDFLWMRLAMI--------QPGDADNYGKLQSMILEQYGEKYFNA 428
            |||:..||:.:...|||...:|:||::|..:        .|.|.....:.|..:||.|||.:|..
Mouse   391 YCIIGRCDITDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTV 455

  Fly   429 RQQPYLYFETLALTGQFEAAIEFLARQDENRAHAVHMAIALFELGLLGSARSVSQPLLSIDIKDP 493
            .|||:|||:.|.||.||||||.||.|.:..|.||||:|:.||||.||..:...|..|||.:..||
Mouse   456 NQQPFLYFQVLFLTAQFEAAIAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDP 520

  Fly   494 QPLRRLNLTRLIRQYVQRFERTDTSEALHYYYTLRCLKDSKGRNMFMACVCDLVVDSGVFDTTIF 558
            ..:||||..||:..|.::||.||..|||.|:|.||..|||:|.|||:.||.:||::|     ..|
Mouse   521 PCMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMFLRCVSELVIES-----REF 580

  Fly   559 DLIFGKRQSSDQNDVNSGLFRQFECPEFDTRTMAAQVGDELAALGNFEMSARLYEMAGKYNLAVK 623
            |:|.||.::....  ..|:..:|..   ||:.:..:|.......|.||.:|:||::|...:..::
Mouse   581 DMILGKLENDGSR--KPGVIDKFTS---DTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLE 640

  Fly   624 HICILMAQVVHLPTLGGSLRERLGQDAQRFNQLLASDSIDVEPKMKSSFVLLQDLLIFFNFYHDG 688
            .:..|::.||...:...|.:|||...|....:...:..|.....:.|:|.||.||:.||:.||.|
Mouse   641 LMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSG 705

  Fly   689 KFNAALDLLRQTQLVPNTLDDVDVVLGNVKQLSGEVIKVLPDVIVAAMEIAQKQYKQLKAGSGSS 753
            ..:.|.|::.:.:|||...:.|:..:...:..|.|:...|.:|::|.|.|...|:|:||..|.||
Mouse   706 HIDRAFDIIDRLKLVPLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSS 770

  Fly   754 LEQTQM------QQLRQRAKALSNMAATMPYRLPNDTNKRLIELELDMH 796
            ..:.|.      .|||.:|:||...|..:|||...|||.||:::|:.|:
Mouse   771 ATRPQRVIEDRDSQLRSQARALITFAGMIPYRTSGDTNARLVQMEVLMN 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-2	NP_650404.1	DUF2461	178..>238	CDD:295279	16/59 (27%)
Nup93-2	NP_650404.1	Nic96	213..781	CDD:282017	213/601 (35%)
Nup93	NP_001344195.1	Nic96	220..802	CDD:309288	211/598 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845449
Domainoid	1	1.000	325	1.000	Domainoid score	I1188
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40971
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1475
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59183
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm42429
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	LDO	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	1	1.000	-	-		X3522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.890