DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup93-2 and npp-13

DIOPT Version :9

Sequence 1:	NP_650404.1	Gene:	Nup93-2 / 41804	FlyBaseID:	FBgn0038274	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_740802.1	Gene:	npp-13 / 171774	WormBaseID:	WBGene00003799	Length:	787	Species:	Caenorhabditis elegans

Alignment Length:	828	Identity:	191/828 - (23%)
Similarity:	349/828 - (42%)	Gaps:	144/828 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VERTLQQVLRA-----TTELHSRVTQTGCKEIQAHILLGSKGVDLPKLNQKLEALSARKTFE--- 82
            ||:.|..:|..     |.:.||         :|..::.|.:|::||....|........|.|
Worm    44 VEQELCGILGGSEGDWTRQTHS---------VQKQMMFGERGIELPSRQPKSHTAEDTLTDEGVV 99

  Fly    83 --PLDVKADTDVRTFLKNERENAILSVIEDTKKNISDSANKQRWAS--MNKVWNEEKTRLLDALI 143
              |..|..|.|     :.|.:..|..|..:|.:...:.....|.|:  ||.....|:    |.|.
Worm   100 DVPEAVMDDID-----EEELDEDISRVKVETDRAFFNHMLLSRPAAVPMNPAQAMER----DNLP 155

  Fly   144 APSQNFIDLQRLPEPTIVNPLCQPRSCLDPLELVYAQELRHYNELLLKSSHRPNLVQKFAH-LSQ 207
            .....|::                ::..|..||::..:|..:    ||:..:.:||..... :.:
Worm   156 FGGGKFVN----------------KNISDRRELIFGDKLHKF----LKNQGKKSLVDLMKEAIDE 200

  Fly   208 SFGDCRLTDMWTLLACVTQISEPLRSDPIKSRQQRPE---------FVTYAKSYLERRYRVFMCS 263
            |..|..|.|:|..:..|.........|.:.:.....|         |..:.::.:||...|   :
Worm   201 SGTDGALGDVWNDVTSVLNRKTSASRDDLTTTANLVEDACKYLQAVFTEHMQTVVERNLEV---A 262

  Fly   264 QVGGSYANNSYQLVVAYV----NHRFRAQQTIGLVDTVREIPLWPLVYYGLRCGAVKVAVEFLRE 324
            :.||......  ||.|::    ...|:.:.     |::..:|.|.:.|:.:|.|.:|.|.|.|..
Worm   263 ERGGIPGTRG--LVNAFLKVGTEESFQPED-----DSIDGMPTWQVTYHCVRAGDMKSASETLNR 320

  Fly   325 AGSSHDEFAQLVADRN----AGETNSKIENQLRLQYANKIRNSTDAYKKAVYCILL-GCDVNEVH 384
            . .|..:.|.|||..|    .|:.:|:::.:|::::.:.:.::.|.||:|:|..|| |.|    .
Worm   321 L-KSFPQCATLVAALNHVAKHGKLDSELKKKLKVEWRHNLAHTKDKYKRALYAALLGGLD----S 380

  Fly   385 GEVAKTIDDFLWMRL--AMIQPGDAD-NYGKLQSMILEQYGEKYF--NARQQPYLYFETLALTGQ 444
            ..:|.|:::::|.:|  ..:.|...| .:.::|..:...|||:||  |...:...:|..|.|:||
Worm   381 AALADTLENWIWFKLYPLHVDPQLTDVLFKEVQKAVSVDYGEQYFMSNGPSEFQYFFTALWLSGQ 445

  Fly   445 FEAAIEFLARQDENRAHAVHMAIALFELGLLGSARSVSQPLLSIDIKDPQPLRRLNLTRLIRQYV 509
            ||.|| :|..:...|..:||:|:...:||.|..::..:..:|.:|..|.... .|||.|||..|.
Worm   446 FERAI-YLLHECGQRVDSVHVAVLAHKLGYLRMSKKSTDEMLVVDQNDSTKC-HLNLARLIVAYT 508

  Fly   510 QRFERTDTSEALHYYYTLRCLKDSKGRNMFMACVCDLVVDSGVFDTTIFDLIFGKRQSSDQNDVN 574
            :.||..|...:|.|::.|:.:....|.::|     ::.|...|:.|...|.|.||.....:.:
Worm   509 KSFELVDVPRSLDYWFLLKGITTPTGSDVF-----EMAVSRSVYLTGQTDEILGKLTPDGRRE-- 566

  Fly   575 SGLFRQFECPEFDTRTMAAQVGDELAALGNFEMSARLYEMAGK-YNLAVKHICILMAQVVHLPTL 638
            .||..::   ..|...:..:|..:....|.::.:..||.:|.| .|.|:    :|.:::..  ||
Worm   567 KGLIDEY---LDDPSEVICRVASDTEITGEWDQAVGLYLLASKPTNAAI----LLSSEISE--TL 622

  Fly   639 GGSLRERLGQDAQRFNQLLASDSIDVEPKMK-----------SSFVLLQDLLIFFNFYHDGKFNA 692
            ....:|::            :|.:.|..:.|           ::..||.||.:.|:...:.:...
Worm   623 RTENKEKI------------ADLVHVAEQFKKVQRGCQASEYATLSLLVDLAVLFDHCRNEEAEI 675

  Fly   693 ALDLLRQTQLVPNTLDDVDVVLGNVKQLSGEVIKVLPDVIVAAME------IAQKQYKQLKAGSG 751
            |..:....:|:|...|.|.|::.....:..:|.:||||:.:..|:      |.|   ...:|..|
Worm   676 AYGISTHLRLIPTEPDQVTVIVNEFHMVPQKVREVLPDMCLHLMKCLVDHCIRQ---STTQANRG 737

  Fly   752 SSLEQTQM----QQLRQRAKALSNMAATMPYRLPNDTNKRLIELELDM 795
            ::...|.|    .:..::.||:...:||:||:.|.....||::|:..:
Worm   738 ANSATTSMFSSSNRYVKQIKAIVLYSATVPYKFPTHVTSRLLQLQASL 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup93-2	NP_650404.1	DUF2461	178..>238	CDD:295279	12/60 (20%)
Nup93-2	NP_650404.1	Nic96	213..781	CDD:282017	146/612 (24%)
npp-13	NP_740802.1	Nic96	206..771	CDD:282017	146/612 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163618
Domainoid	1	1.000	167	1.000	Domainoid score	I2332
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40971
Inparanoid	1	1.050	188	1.000	Inparanoid score	I2582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59183
OrthoDB	1	1.010	-	-		D187731at2759
OrthoFinder	1	1.000	-	-		FOG0002723
OrthoInspector	1	1.000	-	-		otm14348
orthoMCL	1	0.900	-	-		OOG6_103333
Panther	1	1.100	-	-	LDO	PTHR11225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940