Protein Alignment Dph2 and DPH2

DIOPT Version :10

• Sequence 1: NP_650402.1
• Gene: Dph2 / 41802
• FlyBaseID: FBgn0038272
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_012730.1
• Gene: DPH2 / 853643
• SGDID: S000001674
• Length: 534
• Species: Saccharomyces cerevisiae
• Alignment Length: 552
• Identity: 148/552 - (26%)
• Similarity: 242/552 - (43%)
• Gaps: 126/552 - (22%)

  Fly     3 SSETSASAFSSSDTAALERQA---------EVEQPVT----LEQI--WNENHRRSSVDWIRKSGY 52
            |:..|..||...:|..::|.:         |:.|.::    :|.:  :.|.|..          |
Yeast     8 STTQSDVAFQKVETHEIDRSSYLGPCYNSDELMQLISAYYNVEPLVGYLEQHPE----------Y 62

  Fly    53 KRVCLQFPDDYLPHSNAISVGLKELLAPEDVKVFILADTTYGSCCVDEIAAAHVDADSVIHFGNA 117
            :.|.||||||.:..|:.|...|:.......:|.::||||.|.:|||||:||.||.|:.|:|||:|
Yeast    63 QNVTLQFPDDLIKDSSLIVRLLQSKFPHGKIKFWVLADTAYSACCVDEVAAEHVHAEVVVHFGDA 127

  Fly   118 CRSRAARLPVLYLYPELPLDVNVLLSKLQGLRA-ESIDRQVCV---------------------- 159
            |.:....|||:|.:....||:.:::...|  || ..:..::|:
Yeast   128 CLNAIQNLPVVYSFGTPFLDLALVVENFQ--RAFPDLSSKICLMANAPFSKHLSQLYNILKGDLH 190

  Fly   160 YLDIGYQHVYGEKLKKQLSEILEPKELLLELFPPIEAESTTTRETTNLERICIFIG----ADN-- 218
            |.:|.|..|....::::...||:...:      |.:.:....     .|:..:..|    |||
Yeast   191 YTNIIYSQVNTSAVEEKFVTILDTFHV------PEDVDQVGV-----FEKNSVLFGQHDKADNIS 244

  Fly   219 -QRFANLSLTAPAAVQW----------HIYDGSSDSLSSKNPLTAQF--IRRRYFHIEKCKDAQT 270
             :.:....||.|...:.          ||:|.:...:     :|..|  :.|||.::...:.|..
Yeast   245 PEDYHLFHLTTPQDPRLLYLSTVFQSVHIFDPALPGM-----VTGPFPSLMRRYKYMHVARTAGC 304

  Fly   271 LGLIVATLSAEGYLDVVTRLQTMAKGRGIKTQLISVGRINPAKLANFLEIDCFVLIGC------- 328
            :|::|.|||.....:.:..|..:.|.|..|..|..||:.|.||||||.:||.:.::||
Yeast   305 IGILVNTLSLRNTRETINELVKLIKTREKKHYLFVVGKPNVAKLANFEDIDIWCILGCSQSGIIV 369

  Fly   329 -PFNNMYDSKEYYKPIVSVFEAEMALNPAWHMRYPEAYVTDFKQLLPE------GRSFLPFD-AA 385
             .||      |:||||::.:|..:||:.  .:.:...:|.||:..:.|      |:..:... .:
Yeast   370 DQFN------EFYKPIITPYELNLALSE--EVTWTGKWVVDFRDAIDEIEQNLGGQDTISASTTS 426

  Fly   386 DIPENDVSLVSGR-------LRGAVNDSLETGGDPASLALATQ--AKMALM--TTDTGLS-FEDR 438
            |.||.||  |.||       ||...:..||...|..|..|.|:  |..|::  |..|..| .::|
Yeast   427 DEPEFDV--VRGRYTSTSRPLRALTHLELEAADDDDSKQLTTRHTASGAVIKGTVSTSASALQNR 489

  Fly   439 TWQGLDPALGQTE----PAKLQQGLSGIPINY 466
            :|:||......||    .|.:::|:||:...|
Yeast   490 SWKGLGSDFDSTEVDNTGADIEEGISGVARGY 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dph2	NP_650402.1	diphth2_R	44..353	CDD:273013	98/358 (27%)
DPH2	NP_012730.1	DPH2	11..524	CDD:272990	147/549 (27%)