Protein Alignment Dph2 and DPH2

DIOPT Version :10

• Sequence 1: NP_650402.1
• Gene: Dph2 / 41802
• FlyBaseID: FBgn0038272
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001375.2
• Gene: DPH2 / 1802
• HGNCID: 3004
• Length: 489
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 156/547 - (28%)
• Similarity: 236/547 - (43%)
• Gaps: 149/547 - (27%)

  Fly     9 SAFSSSDTAALERQAEVEQPVT----------LEQIWNENHRRSSVDWIRKSGYKRVCLQFPDDY 63
            |.|||...|||:|:..|...:|          ||::         ..::|..|.:||.|||||..
Human     3 SMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERV---------AGFVRDLGCERVALQFPDQL 58

  Fly    64 LPHSNAISVGLKELLAPEDVKVFILADTTYGSCCVDEIAAAHVDADSVIHFGNACRSRAAR-LPV 127
            |..:.|::..|:|....   |:|||.||.|||||||.:.|....|.::||||.||.|..|| |||
Human    59 LGDAVAVAARLEETTGS---KMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPV 120

  Fly   128 LYLYPELPLDVNVLLSKLQGLRAESIDRQVCVYLDIGYQHVYGEKLKKQLSEILEPKELLLELFP 192
            .::                 ||..|:..::||              |...::..:||..::.|..
Human   121 AFV-----------------LRQRSVALELCV--------------KAFEAQNPDPKAPVVLLSE 154

  Fly   193 P-----IEAESTTTRETTNLERICIFIGADNQRFANLSLTAPAAVQ------------------- 233
            |     :||.:|..|                .|:.:|.:::||..|
Human   155 PACAHALEALATLLR----------------PRYLDLLVSSPAFPQPVGSLSPEPMPLERFGRRF 203

  Fly   234 -----------WHIYDGSSDS----------------------LSSKNPLTAQF----------- 254
                       ...|.|.|.:                      .||..|.|.:.
Human   204 PLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLR 268

  Fly   255 IRRRYFHIEKCKDAQTLGLIVATLSAEGYLDVVTRLQTMAKGRGIKTQLISVGRINPAKLANFLE 319
            .||||. :|:.:||:.:||:..||....:.:.:..|:.:.:..|.::.::::||..|||||||.|
Human   269 ARRRYL-VERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPE 332

  Fly   320 IDCFVLIGCPFNNMYD--SKEYYKPIVSVFEAEMALNPAWHMRYPEAYVTDFKQLLPEGRSF--- 379
            :|.|||:.||...:..  |..:::||::..|.|.|.||||.......::|.:..||| |..|
Human   333 VDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLP-GSPFHVA 396

  Fly   380 LPFDAADIPEN-DVSLVSGRLRGAVNDSLETGGDPASLALATQAKMALMTTDTGLSF-EDRTWQG 442
            ||...:::.|. ||||::|.||..  .:.::..|..||||..:.::.|..:....|| ..|:|||
Human   397 LPPPESELWETPDVSLITGDLRPP--PAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQG 459

  Fly   443 LDPALGQTEPAKLQQGLSGIPINYSHQ 469
            |:|.||||...:...|..||.|.|..:
Human   460 LEPRLGQTPVTEAVSGRRGIAIAYEDE 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dph2	NP_650402.1	diphth2_R	44..353	CDD:273013	100/379 (26%)
DPH2	NP_001375.2	diphth2_R	32..368	CDD:273013	102/395 (26%)